Organoids in COVID-19: can we break the glass ceiling?

被引：0
作者：
Chau, Chiu Wang [1 ]
Sugimura, Ryohichi [1 ,2 ]
机构：
[1] Univ Hong Kong, Li Ka Shing Fac Med, Sch Biomed Sci, Pokfulam, 21 Sassoon Rd, Hong Kong 99077, Peoples R China
[2] Ctr Translat Stem Cell Biol, 17 Sci Pk W Ave,Sci Pk, Hong Kong 999077, Peoples R China
来源：
JOURNAL OF LEUKOCYTE BIOLOGY | 2024年 / 115卷 / 01期
关键词：
COVID-19; SARS-CoV-2; disease modeling; organoids; KIDNEY ORGANOIDS; SARS-COV-2; INFECTION; CEREBRAL ORGANOIDS; LUNG; CELLS; DISEASE; ACE2; INHIBITION; GENERATION; RESPONSES;
D O I：
10.1093/jleuko/qiad098
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
COVID-19 emerged in September 2020 as a disease caused by the virus SARS-CoV-2. The disease presented as pneumonia at first but later was shown to cause multisystem infections and long-term complications. Many efforts have been put into discovering the exact pathogenesis of the disease. In this review, we aim to discuss an emerging tool in disease modeling, organoids, in the investigation of COVID-19. This review will introduce some methods and breakthroughs achieved by organoids and the limitations of this system.
引用
收藏
页码：85 / 99
页数：15
相关论文
共 159 条
  • [1] Dysregulation of type I interferon responses in COVID-19
    Acharya, Dhiraj
    Liu, GuanQun
    Gack, Michaela U.
    [J]. NATURE REVIEWS IMMUNOLOGY, 2020, 20 (07) : 397 - 398
  • [2] Tropism of SARS-CoV-2 for human cortical astrocytes
    Andrews, Madeline G.
    Mukhtar, Tanzila
    Eze, Ugomma C.
    Simoneau, Camille R.
    Ross, Jayden
    Parikshak, Neelroop
    Wang, Shaohui
    Zhou, Li
    Koontz, Mark
    Velmeshev, Dmitry
    Siebert, Clara-Vita
    Gemenes, Kaila M.
    Tabata, Takako
    Perez, Yonatan
    Wang, Li
    Mostajo-Radji, Mohammed A.
    de Majo, Martina
    Donohue, Kevin C.
    Shin, David
    Salma, Jahan
    Pollen, Alex A.
    Nowakowski, Tomasz J.
    Ullian, Erik
    Kumar, G. Renuka
    Winkler, Ethan A.
    Crouch, Elizabeth E.
    Ott, Melanie
    Kriegstein, Arnold R.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2022, 119 (30)
  • [3] SARS-CoV-2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis
    Bailey, Adam L.
    Dmytrenko, Oleksandr
    Greenberg, Lina
    Bredemeyer, Andrea L.
    Ma, Pan
    Liu, Jing
    Penna, Vinay
    Winkler, Emma S.
    Sviben, Sanja
    Brooks, Erin
    Nair, Ajith P.
    Heck, Kent A.
    Rali, Aniket S.
    Simpson, Leo
    Saririan, Mehrdad
    Hobohm, Dan
    Stump, W. Tom
    Fitzpatrick, James A.
    Xie, Xuping
    Zhang, Xianwen
    Shi, Pei-Yong
    Hinson, J. Travis
    Gi, Weng-Tein
    Schmidt, Constanze
    Leuschner, Florian
    Lin, Chieh-Yu
    Diamond, Michael S.
    Greenberg, Michael J.
    Lavine, Kory J.
    [J]. JACC-BASIC TO TRANSLATIONAL SCIENCE, 2021, 6 (04): : 331 - 345
  • [4] Differentiation of Cardiomyocytes from Human Pluripotent Stem Cells Using Monolayer Culture
    Batalov, Ivan
    Feinberg, Adam W.
    [J]. BIOMARKER INSIGHTS, 2015, 10 : 71 - 76
  • [5] Evidence in favor of the essentiality of human cell membrane-bound ACE2 and against soluble ACE2 for SARS-CoV-2 infectivity
    Batlle, Daniel
    Monteil, Vanessa
    Garreta, Elena
    Hassler, Luise
    Wysocki, Jan
    Chandar, Vasuretha
    Schwartz, Robert E.
    Mirazimi, Ali
    Montserrat, Nuria
    Bader, Michael
    Penninger, Josef M.
    [J]. CELL, 2022, 185 (11) : 1837 - 1839
  • [6] Role of ADAM17 in the ectodomain shedding of TNF-α and its receptors by neutrophils and macrophages
    Bell, Jessica H.
    Herrera, Amy H.
    Li, Ying
    Walcheck, Bruce
    [J]. JOURNAL OF LEUKOCYTE BIOLOGY, 2007, 82 (01) : 173 - 176
  • [7] A CRISPR/Cas9 genetically engineered organoid biobank reveals essential host factors for coronaviruses
    Beumer, Joep
    Geurts, Maarten H.
    Lamers, Mart M.
    Puschhof, Jens
    Zhang, Jingshu
    van der Vaart, Jelte
    Mykytyn, Anna Z.
    Breugem, Tim, I
    Riesebosch, Samra
    Schipper, Debby
    van den Doel, Petra B.
    de Lau, Wim
    Pleguezuelos-Manzano, Cayetano
    Busslinger, Georg
    Haagmans, Bart L.
    Clevers, Hans
    [J]. NATURE COMMUNICATIONS, 2021, 12 (01)
  • [8] Spatial proteomics in three-dimensional intact specimens
    Bhatia, Harsharan Singh
    Brunner, Andreas-David
    Oeztuerk, Furkan
    Kapoor, Saketh
    Rong, Zhouyi
    Mai, Hongcheng
    Thielert, Marvin
    Ali, Mayar
    Al-Maskari, Rami
    Paetzold, Johannes Christian
    Kofler, Florian
    Todorov, Mihail Ivilinov
    Molbay, Muge
    Kolabas, Zeynep Ilgin
    Negwer, Moritz
    Hoeher, Luciano
    Steinke, Hanno
    Dima, Alina
    Gupta, Basavdatta
    Kaltenecker, Doris
    Caliskan, Ozum Sehnaz
    Brandt, Daniel
    Krahmer, Natalie
    Mueller, Stephan
    Lichtenthaler, Stefan Frieder
    Hellal, Farida
    Bechmann, Ingo
    Menze, Bjoern
    Theis, Fabian
    Mann, Matthias
    Ertuerk, Ali
    [J]. CELL, 2022, 185 (26) : 5040 - +
  • [9] Biemiller J., 2022, Res Sq, DOI [10.21203/rs.3.rs-62758/v1, DOI 10.21203/RS.3.RS-62758/V1, 10.21203/rs.3.rs-1650728/v1]
  • [10] Xenograft and organoid model systems in cancer research
    Bleijs, Margit
    van de Wetering, Marc
    Clevers, Hans
    Drost, Jarno
    [J]. EMBO JOURNAL, 2019, 38 (15)
12345678910