ROS-Activated TRPM2 Channel: Calcium Homeostasis in Cardiovascular/renal System and Speculation in Cardiorenal Syndrome

被引：2

作者：

Chen, Zihan ^{[1
,2
]}

Cheng, Zaihua ^{[1
]}

Ding, Congcong ^{[1
]}

Cao, Tianyu ^{[3
]}

Chen, Ling ^{[4
]}

Wang, Hong ^{[5
]}

Li, Junpei ^{[1
]}

Huang, Xiao ^{[1
]}

机构：

[1] Nanchang Univ, Dept Cardiol, Affiliated Hosp 2, Nanchang, Peoples R China

[2] Nanchang Univ, Med Dept, Queen Mary Sch, Nanchang, Peoples R China

[3] Univ Calif Santa Barbara, Biol Anthropol, Santa Barbara, CA USA

[4] First Peoples Hosp Jiujiang, Dept Cardiol, Jiujiang, Peoples R China

[5] Temple Univ, Lewis Katz Sch Med, Philadelphia, PA USA

来源：

CARDIOVASCULAR DRUGS AND THERAPY | 2023年 / 39卷 / 3期

基金：

中国国家自然科学基金;

关键词：

TRPM2; channel; Oxidative stress; Cardiovascular; Kidney; Cardiorenal syndrome; OXIDATIVE STRESS; KIDNEY-DISEASE; SYNDROME PATHOPHYSIOLOGY; ENDOPLASMIC-RETICULUM; NEUTROPHIL MIGRATION; ATRIAL-FIBRILLATION; REPERFUSION INJURY; RENAL-FUNCTION; RISK-FACTOR; HEART;

D O I：

10.1007/s10557-023-07531-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The transient receptor potential melastatin 2 (TRPM2) channel is a nonselective calcium channel that is sensitive to oxidative stress (OS), and is widely expressed in multiple organs, such as the heart, kidney, and brain, which is inextricably related to calcium dyshomeostasis and downstream pathological events. Due to the increasing global burden of kidney or cardiovascular diseases (CVDs), safe and efficient drugs specific to novel targets are imperatively needed. Notably, investigation of the possibility to regard the TRPM2 channel as a new therapeutic target in ROS-related CVDs or renal diseases is urgently required because the roles of the TRPM2 channel in heart or kidney diseases have not received enough attention and thus have not been fully elaborated. Therefore, we aimed to review the involvement of the TRPM2 channel in cardiovascular disorders related to kidney or typical renal diseases and attempted to speculate about TRPM2-mediated mechanisms of cardiorenal syndrome (CRS) to provide representative perspectives for future research about novel and effective therapeutic strategies.

引用

页码：615 / 631

页数：17

共 3 条

[1] Deficiency of ROS-Activated TRPM2 Channel Protects Neurons from Cerebral Ischemia-Reperfusion Injury through Upregulating Autophagy
Hu, Xupang
Wu, Lijuan
Liu, Xingyu
Zhang, Yi
Xu, Min
Fang, Qiuyuan
Lu, Lin
Niu, Jianguo
Abd El-Aziz, Tarek Mohamed
Jiang, Lin-Hua
Li, Fangfang
Yang, Wei
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2021, 2021
[2] Alteration in Intracellular Zn2+ Homeostasis as a Result of TRPM2 Channel Activation Contributes to ROS-Induced Hippocampal Neuronal Death
Li, Xin
Yang, Wei
Jiang, Lin-Hua
FRONTIERS IN MOLECULAR NEUROSCIENCE, 2017, 10
[3] Role of H2O2-activated TRPM2 calcium channel in oxidant-induced endothelial injury
Hecquet, Claudie M.
Malik, Asrar B.
THROMBOSIS AND HAEMOSTASIS, 2009, 101 (04) : 619 - 625

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