Characterizing metal-biomolecule interactions by mass spectrometry

被引：3
|
作者：
Janisse, Samuel E. [1 ]
Fernandez, Rebeca L. [1 ]
Heffern, Marie C. [1 ]
机构：
[1] Univ Calif Davis, Dept Chem, One Shields Dr, Davis, CA 95616 USA
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 2023年 / 48卷 / 09期
关键词：
SIZE-EXCLUSION CHROMATOGRAPHY; INDUCTIVELY-COUPLED PLASMA; AFFINITY-CHROMATOGRAPHY; C-PEPTIDE; CLINICAL-PRACTICE; BINDING PROTEINS; COPPER; COMPLEXES; SITES; COORDINATION;
D O I：
10.1016/j.tibs.2023.06.006
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Metal micronutrients are essential for life and exist in a delicate balance to main-tain an organism's health. The labile nature of metal-biomolecule interactions clouds the understanding of metal binders and metal-mediated conformational changes that are influential to health and disease. Mass spectrometry (MS)-based methods and technologies have been developed to better understand metal micronutrient dynamics in the intra-and extracellular environment. In this review, we describe the challenges associated with studying labile metals in human biology and highlight MS-based methods for the discovery and study of metal-biomolecule interactions.
引用
收藏
页码：815 / 825
页数：11
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