Higher Availability of Long-Chain Monounsaturated Fatty Acids in Preterm than in Full-Term Human Milk

被引:3
作者
Marosvolgyi, Tamas [1 ,2 ]
Dergez, Timea [1 ]
Szentpeteri, Jozsef L. [3 ]
Szabo, Eva [2 ,4 ]
Decsi, Tamas [2 ]
机构
[1] Univ Pecs, Inst Bioanal, Med Sch, H-7624 Pecs, Hungary
[2] Univ Pecs, Med Sch, Dept Paediat, H-7623 Pecs, Hungary
[3] Univ Pecs, Med Sch, Inst Transdisciplinary Discoveries, H-7624 Pecs, Hungary
[4] Univ Pecs, Med Sch, Dept Biochem & Med Chem, H-7624 Pecs, Hungary
来源
LIFE-BASEL | 2023年 / 13卷 / 05期
关键词
colostrum; erucic acid; gondoic acid; human milk; long-chain monounsaturated fatty acids (LCMUFAs); mature milk; nervonic acid; transient milk; BREAST-MILK; NERVONIC ACID; PREMATURE-INFANTS; LIPID-COMPOSITION; GESTATIONAL-AGE; MATURE MILK; MOTHERS; LACTATION; COLOSTRUM; DIET;
D O I
10.3390/life13051205
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
While the role of n-3 and n-6 long-chain polyunsaturated fatty acids (LCPUFAs) in the maturation of the infantile nervous system is extensively studied and relatively well-characterized, data on the potential developmental importance of the n-9 long-chain monounsaturated fatty acid (LCMUFA), nervonic acid (NA, C24:1n-9) are scarce and ambiguous. Therefore, the aim of the present study was to reanalyze our available data on the contribution of NA and its LCMUFA precursors, gondoic acid (C20:1n-9) and erucic acid (EA, C22:1n-9) to the fatty acid composition of human milk (HM) during the first month of lactation in mothers of both preterm (PT) and full-term (FT) infants. HM samples were obtained daily during the first week of lactation, and then on the 14th, 21st, and 28th days. Values of the LCMUFAs, C20:1n-9, EA, and NA were significantly higher in colostrum than in transient and mature HM. Consequently, there were highly significant inverse associations between LCMUFA values and the duration of lactation. Moreover, C20:1n-9, EA, and NA values were monotonously, considerably, and at many timepoints significantly higher in PT than in FT HM samples. By the 28th day of lactation, summarized LCMUFA values in PT HM samples declined to the level measured in FT HM samples on the first day of lactation; however, EA and NA values were still significantly higher in PT than in FT HM on the 28th day. Significantly higher availability of LCMUFAs in PT than in FT HM underpins the potential biological role of this hitherto somewhat neglected group of fatty acids.
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页数:12
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