Loss of SV2A promotes human neural stem cell apoptosis via p53 signaling

被引：3
|
作者：
Yu, Hongxiang [1 ]
Han, Yingying [1 ]
Cui, Can [1 ]
Li, Gang [1 ]
Zhang, Bei [1 ]
机构：
[1] Tongji Univ, Shanghai East Hosp, Sch Med, Dept Neurol, Shanghai 200092, Peoples R China
来源：
NEUROSCIENCE LETTERS | 2023年 / 800卷
基金：
中国国家自然科学基金;
关键词：
Synaptic vesicle protein 2A; Neural stem cell; P53 signaling pathway; Apoptosis; EXPRESSION; VESICLES;
D O I：
10.1016/j.neulet.2023.137125
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
This study investigated the role of synaptic vesicle protein 2A (SV2A) in the regulation of human induced pluripotent stem cell-derived neural stem cells (NSCs). SV2A was highly expressed in NSCs. SV2A knockdown promotes apoptosis, which was associated with an upregulation of genes involved in p53 signaling as determined by transcriptome analysis. Treatment with the small molecule p53 inhibitor pifithrin-alpha reversed the promotion of NSC apoptosis induced by loss of SV2A. These results demonstrate that SV2A plays an important role in regu-lating NSC survival via the p53 signaling pathway.
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页数：7
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