Clinical Features, Risk Factors, and Management of Candida Keratitis

被引：6
作者：
Masoumi, Ahmad [1 ,2 ]
Soleimani, Mohammad [1 ,2 ,3 ]
Azizkhani, Momeneh [1 ,2 ]
Izadi, Alireza [1 ,2 ]
Cheraqpour, Kasra [1 ,2 ]
Tabatabaei, Seyed Ali [1 ,2 ]
Khodaveisi, Sadegh [1 ,2 ]
Aminzadeh, Mehdi [1 ,2 ]
机构：
[1] Univ Tehran Med Sci, Ophthalmol Dept, Tehran, Iran
[2] Univ Tehran Med Sci, Farabi Eye Hosp, Eye Res Ctr, Tehran, Iran
[3] Univ Tehran Med Sci, Farabi Eye Hosp, Eye Res Ctr, South Kargar St,Qazvin Sq, Tehran 1336616351, Iran
来源：
OCULAR IMMUNOLOGY AND INFLAMMATION | 2024年 / 32卷 / 07期
关键词：
Candida keratitis; Candida albicans; fungal keratitis; Non-albicans; risk factor; FUNGAL KERATITIS; EPIDEMIOLOGY; DIAGNOSIS; OUTCOMES; UPDATE;
D O I：
10.1080/09273948.2023.2203752
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Background/AimsTo determine the clinical features, predisposing factors, and management of infectious keratitis caused by Candida spp.MethodsRetrospective chart review.ResultsThe medical records of 52 patients (54 eyes) with Candida keratitis were available for statistical analysis. Thinning of the corneal stroma was identified in 34 eyes (63.0%), and corneal perforation occurred in 16 eyes (29.6%). Corneal thinning and perforation were more common in Candida albicans compared with non-albicans (P-val < .001, P = .09, respectively). The most common predisposing factors for Candida keratitis were topical steroid use (21 patients, 40.4%), previous corneal transplantation (17 patients, 32.7%), and preexisting ocular surface disease (15 patients, 28.8%). Fourteen eyes (25.9%) required cyanoacrylate glue application and 10 eyes (18.5%) underwent therapeutic penetrating keratoplasty (TPK).ConclusionLocal immunosuppression and ocular surface disease play an important role in Candida keratitis. C. albicans appears to be more invasive compared with non-albicans spp.
引用
收藏
页码：1169 / 1174
页数：6
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