The Liver Tumor Segmentation Benchmark (LiTS)

被引:527
作者
Bilic, Patrick [1 ]
Christ, Patrick [1 ]
Li, Hongwei Bran [1 ,2 ]
Vorontsov, Eugene [3 ]
Ben-Cohen, Avi [5 ]
Kaissis, Georgios [10 ,12 ,15 ]
Szeskin, Adi [18 ]
Jacobs, Colin [4 ]
Mamani, Gabriel Efrain Humpire [4 ]
Chartrand, Gabriel [26 ]
Lohoefer, Fabian [12 ]
Holch, Julian Walter [29 ,30 ,69 ]
Sommer, Wieland [32 ]
Hofmann, Felix [31 ,32 ]
Hostettler, Alexandre [36 ]
Lev-Cohain, Naama [38 ]
Drozdzal, Michal [34 ]
Amitai, Michal Marianne [35 ]
Vivanti, Refael [37 ]
Sosna, Jacob [38 ]
Ezhov, Ivan [1 ]
Sekuboyina, Anjany [1 ,2 ]
Navarro, Fernando [1 ,76 ,78 ]
Kofler, Florian [1 ,13 ,57 ,78 ]
Paetzold, Johannes C. [15 ,16 ]
Shit, Suprosanna [1 ]
Hu, Xiaobin [1 ]
Lipkova, Jana [17 ]
Rempfler, Markus [1 ]
Piraud, Marie [1 ,57 ]
Kirschke, Jan [13 ]
Wiestler, Benedikt [13 ]
Zhang, Zhiheng [14 ]
Huelsemeyer, Christian [1 ]
Beetz, Marcel [1 ]
Ettlinger, Florian [1 ]
Antonelli, Michela [9 ]
Bae, Woong [73 ]
Bellver, Miriam [43 ]
Bi, Lei [61 ]
Chen, Hao [39 ]
Chlebus, Grzegorz [62 ,64 ]
Dam, Erik B. [72 ]
Dou, Qi [41 ]
Fu, Chi-Wing [41 ]
Georgescu, Bogdan [60 ]
Giro-I-Nieto, Xavier [45 ]
Gruen, Felix [28 ]
Han, Xu [77 ]
Heng, Pheng-Ann [41 ]
机构
[1] Tech Univ Munich, Dept Informat, Munich, Germany
[2] Univ Zurich, Dept Quantitat Biomed, Zurich, Switzerland
[3] Ecole Polytech Montreal, Montreal, PQ, Canada
[4] Radboud Univ Nijmegen, Dept Med Imaging, Med Ctr, Nijmegen, Netherlands
[5] Tel Aviv Univ, Dept Biomed Engn, Tel Aviv, Israel
[6] German Canc Consortium DKTK, Munich, Germany
[7] Heidelberg Univ Hosp, Dept Radiat Oncol, Pattern Anal & Learning Grp, Heidelberg, Germany
[8] Philips Res China, Philips China Innovat Campus, Shanghai, Peoples R China
[9] Kings Coll London, Sch Biomed Engn & Imaging Sci, London, England
[10] Tech Univ Munich, Inst AI Med, Munich, Germany
[11] Guangdong Univ Foreign Studies, Dept Comp Sci, Guangzhou, Peoples R China
[12] Tech Univ Munich, Inst Diagnost & Intervent Radiol, Klinikum Rechts Isar, Munich, Germany
[13] Tech Univ Munich, Inst Diagnost & Intervent Neuroradiol, Klinikum Rechts Isar, Munich, Germany
[14] Nanjing Univ, Dept Hepatobiliary Surg, Affiliated Drum Tower Hosp, Med Sch, Nanjing, Peoples R China
[15] Imperial Coll London, Dept Comp, London, England
[16] Helmholtz Zentrum Munchen, Inst Tissue Engn & Regenerat Med, Neuherberg, Germany
[17] Harvard Med Sch, Brigham & Womens Hosp, Boston, MA 02115 USA
[18] Hebrew Univ Jerusalem, Sch Comp Sci & Engn, Jerusalem, Israel
[19] Univ Penn, Ctr Biomed Image Comp & Analyt CBICA, Philadelphia, PA 19104 USA
[20] CGG Serv Singapore Pte Ltd, Singapore, Singapore
[21] Indian Inst Technol Madras, Dept Engn Design, Med Imaging & Reconstruct Lab, Madras, Tamil Nadu, India
[22] Sensetime, Shanghai, Peoples R China
[23] Univ Penn, Perelman Sch Med, Dept Radiol, Philadelphia, PA 19104 USA
[24] Univ Penn, Perelman Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA
[25] Tencent Healthcare Shenzhen Co Ltd, Shenzhen, Peoples R China
[26] Univ Montreal Hosp Res Ctr CRCHUM Montreal, Montreal, PQ, Canada
[27] Univ Montreal, Dept Radiol Radiat Oncol & Nucl Med, Montreal, PQ, Canada
[28] Tech Univ Carolo Wilhelmina Braunschweig, Inst Control Engn, Braunschweig, Germany
[29] Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Med 3, Munich, Germany
[30] Comprehens Canc Ctr Munich, Munich, Germany
[31] Ludwig Maximilians Univ Munchen, Dept Gen Visceral & Transplantat Surg, Univ Hosp, Munich, Germany
[32] Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Radiol, Munich, Germany
[33] LMU Klinikum Munich, Dept Hematol Oncol, Munich, Germany
[34] Polytech Montreal, Mila, PQ, Canada
[35] Tel Aviv Univ, Sheba Med Ctr, Dept Diagnost Radiol, Tel Aviv, Israel
[36] Inst Rech Canc Appareil Digestif IRCAD, Dept Surg Data Sci, Strasbourg, France
[37] Rafael Adv Def Syst, Haifa, Israel
[38] Hadassah Univ, Dept Radiol, Med Ctr, Jerusalem, Israel
[39] Hong Kong Univ Sci & Technol, Dept Comp Sci & Engn, Hong Kong, Peoples R China
[40] Univ Hong Kong, Dept Elect & Elect Engn, Hong Kong, Peoples R China
[41] Chinese Univ Hong Kong, Dept Comp Sci & Engn, Hong Kong, Peoples R China
[42] KTH Royal Inst Technol, Dept Biomed Engn & Hlth Syst, Stockholm, Sweden
[43] Barcelona Supercomp Ctr, Barcelona, Spain
[44] ETH Zurich ETHZ, Zurich, Switzerland
[45] Univ Politecn Cataluna, Signal Theory & Commun Dept, Catalonia, Spain
[46] Univ Politecn Cataluna, Catalonia, Spain
[47] Univ Tubingen, Tubingen, Germany
[48] Heidelberg Univ, Mannheim Inst Intelligent Syst Med, Dept Med Mannheim, Heidelberg, Germany
[49] Heidelberg Univ, Interdisciplinary Ctr Sci Comp IWR, Heidelberg, Germany
[50] Heidelberg Univ, Cent Inst Comp Engn ZITI, Heidelberg, Germany
关键词
Segmentation; Liver; Liver tumor; Deep learning; Benchmark; CT; STATISTICAL SHAPE MODEL; SURGICAL RESECTION; CT; BURDEN; METASTASES; CANCER; ALGORITHM; LESIONS; RECIST; TISSUE;
D O I
10.1016/j.media.2022.102680
中图分类号
TP18 [人工智能理论];
学科分类号
081104 ; 0812 ; 0835 ; 1405 ;
摘要
In this work, we report the set-up and results of the Liver Tumor Segmentation Benchmark (LiTS), which was organized in conjunction with the IEEE International Symposium on Biomedical Imaging (ISBI) 2017 and the International Conferences on Medical Image Computing and Computer-Assisted Intervention (MICCAI) 2017 and 2018. The image dataset is diverse and contains primary and secondary tumors with varied sizes and appearances with various lesion-to-background levels (hyper-/hypo-dense), created in collaboration with seven hospitals and research institutions. Seventy-five submitted liver and liver tumor segmentation algorithms were trained on a set of 131 computed tomography (CT) volumes and were tested on 70 unseen test images acquired from different patients. We found that not a single algorithm performed best for both liver and liver tumors in the three events. The best liver segmentation algorithm achieved a Dice score of 0.963, whereas, for tumor segmentation, the best algorithms achieved Dices scores of 0.674 (ISBI 2017), 0.702 (MICCAI 2017), and 0.739 (MICCAI 2018). Retrospectively, we performed additional analysis on liver tumor detection and revealed that not all top-performing segmentation algorithms worked well for tumor detection. The best liver tumor detection method achieved a lesion-wise recall of 0.458 (ISBI 2017), 0.515 (MICCAI 2017), and 0.554 (MICCAI 2018), indicating the need for further research. LiTS remains an active benchmark and resource for research, e.g., contributing the liver-related segmentation tasks in http://medicaldecathlon.com/. In addition, both data and online evaluation are accessible via https://competitions.codalab.org/competitions/17094.
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页数:24
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