Trans-ε-viniferin as an inhibitor of TMEM16A preventing intestinal smooth muscle contraction

被引：1
|
作者：
Liu, Xin-Yi [1 ]
Zhao, Yan [1 ]
Jin, Ling-Ling [2 ]
Pang, Yue [1 ]
Yu, Bo [1 ]
机构：
[1] Liaoning Normal Univ, Sch Life Sci, Liaoning Prov Key Lab Biotechnol & Drug Discovery, Dalian 116081, Peoples R China
[2] Dalian Med Univ, Coll Basic Med Sci, Dalian 116044, Peoples R China
来源：
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2023年 / 25卷 / 09期
关键词：
Trans-epsilon-viniferin; TMEM16A; inhibitor; smooth muscle contraction; INTERSTITIAL-CELLS; CAJAL; EXPRESSION;
D O I：
10.1080/10286020.2023.2165067
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
TMEM16A regulator is an important tool to study the physio-logical functions and pathogenesis related to TMEM16A. In the present study, trans-e-viniferin (TV) was identified as a TMEM16A inhibitor with inhibitory activity against TMEM16A mediated Cl- currents, which was reversible, without affecting intracytoplasmic Ca2 thorn concentration and TMEM16A protein expression. TV inhib-ited intestinal peristalsis and prolonged gastrointestinal transport time. TV could inhibit autonomic and Eact-stimulated intestinal contractility, and was equally effective in ACh-and HA-induced high contractile states. The results indicate that TV significantly inhibits the intestinal smooth muscle contraction, which may be applied in the treatment of TMEM16A-related intestinal dynamic abnormalities. [GRAPHICS]
引用
收藏
页码：867 / 879
页数：13
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