Trans-ε-viniferin as an inhibitor of TMEM16A preventing intestinal smooth muscle contraction

被引：2

作者：

Liu, Xin-Yi ^{[1
]}

Zhao, Yan ^{[1
]}

Jin, Ling-Ling ^{[2
]}

Pang, Yue ^{[1
]}

Yu, Bo ^{[1
]}

机构：

[1] Liaoning Normal Univ, Sch Life Sci, Liaoning Prov Key Lab Biotechnol & Drug Discovery, Dalian 116081, Peoples R China

[2] Dalian Med Univ, Coll Basic Med Sci, Dalian 116044, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2023年 / 25卷 / 09期

关键词：

Trans-epsilon-viniferin; TMEM16A; inhibitor; smooth muscle contraction; INTERSTITIAL-CELLS; CAJAL; EXPRESSION;

D O I：

10.1080/10286020.2023.2165067

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

TMEM16A regulator is an important tool to study the physio-logical functions and pathogenesis related to TMEM16A. In the present study, trans-e-viniferin (TV) was identified as a TMEM16A inhibitor with inhibitory activity against TMEM16A mediated Cl- currents, which was reversible, without affecting intracytoplasmic Ca2 thorn concentration and TMEM16A protein expression. TV inhib-ited intestinal peristalsis and prolonged gastrointestinal transport time. TV could inhibit autonomic and Eact-stimulated intestinal contractility, and was equally effective in ACh-and HA-induced high contractile states. The results indicate that TV significantly inhibits the intestinal smooth muscle contraction, which may be applied in the treatment of TMEM16A-related intestinal dynamic abnormalities. [GRAPHICS]

引用

页码：867 / 879

页数：13

共 24 条

[1] Screening of Natural Stilbene Oligomers fromVitis viniferafor Anticancer Activity on Human Hepatocellular Carcinoma Cells
Aja, Iris
Begona Ruiz-Larrea, M.
Courtois, Arnaud
Krisa, Stephanie
Richard, Tristan
Ruiz-Sanz, Jose-Ignacio
[J]. ANTIOXIDANTS, 2020, 9 (06)
[2] The Oral Bioavailability of Trans-Resveratrol from a Grapevine-Shoot Extract in Healthy Humans is Significantly Increased by Micellar Solubilization
Calvo-Castro, Laura A.
Schiborr, Christina
David, Franziska
Ehrt, Heidi
Voggel, Jenny
Sus, Nadine
Behnam, Dariush
Bosy-Westphal, Anja
Frank, Jan
[J]. MOLECULAR NUTRITION & FOOD RESEARCH, 2018, 62 (09)
[3] Identification of Resveratrol, an Herbal Compound, as an Activator of the Calcium-Activated Chloride Channel, TMEM16A
Chai, Ran
Chen, Yafei
Yuan, Hongbo
Wang, Xuzhao
Guo, Shuai
Qi, Jinlong
Zhang, Hailin
Zhan, Yong
An, Hailong
[J]. JOURNAL OF MEMBRANE BIOLOGY, 2017, 250 (05) : 483 - 492
[4] Differential gene expression in functional classes of interstitial cells of Cajal in murine small intestine
Chen, Hui
Oerdoeg, Tamas
Chen, Junwei
Young, David L.
Bardsley, Michael R.
Redelman, Doug
Ward, Sean M.
Sanders, Kenton M.
[J]. PHYSIOLOGICAL GENOMICS, 2007, 31 (03) : 492 - 509
[5] Mechanism of persistent hyperalgesia in neuropathic pain caused by chronic constriction injury
Chen, Qin-Yi
Tan, Chao-Yang
Wang, Yang
Ma, Ke-Tao
Li, Li
Si, Jun-Qiang
[J]. NEURAL REGENERATION RESEARCH, 2019, 14 (06) : 1091 - 1098
[6] Choi Seok, 2018, Cell Physiol Biochem, V51, P2887, DOI 10.1159/000496041
[7] The multifaceted role of TMEM16A in cancer
Crottes, David
Jan, Lily Yeh
[J]. CELL CALCIUM, 2019, 82
[8] TMEM16C facilitates Na+-activated K+ currents in rat sensory neurons and regulates pain processing
Huang, Fen
Wang, Xidao
Ostertag, Eric M.
Nuwal, Tulip
Huang, Bo
Jan, Yuh-Nung
Basbaum, Allan I.
Jan, Lily Yeh
[J]. NATURE NEUROSCIENCE, 2013, 16 (09) : 1284 - U166
[9] Expression of anoctamin 1/TMEM16A by interstitial cells of Cajal is fundamental for slow wave activity in gastrointestinal muscles
Hwang, Sung Jin
Blair, Peter J. A.
Britton, Fiona C.
O'Driscoll, Kate E.
Hennig, Grant
Bayguinov, Yulia R.
Rock, Jason R.
Harfe, Brian D.
Sanders, Kenton M.
Ward, Sean M.
[J]. JOURNAL OF PHYSIOLOGY-LONDON, 2009, 587 (20): : 4887 - 4904
[10] Recent advances in TMEM16A: Structure, function, and disease
Ji, Qiushuang
Guo, Shuai
Wang, Xuzhao
Pang, Chunli
Zhan, Yong
Chen, Yafei
An, Hailong
[J]. JOURNAL OF CELLULAR PHYSIOLOGY, 2019, 234 (06) : 7856 - 7873

← 1 2 3 →