FDG-PET/MRI for the preoperative diagnosis and staging of peritoneal carcinomatosis: a prospective multireader pilot study

被引：4

作者：

Violi, Naik Vietti ^{[1
,2
]}

Gavane, Somali ^{[3
]}

Argiriadi, Pamela ^{[3
]}

Law, Amy ^{[3
]}

Heiba, Sherif ^{[3
]}

Bekhor, Eliahu Y. ^{[4
]}

Babb, James S. ^{[5
]}

Ghesani, Munir ^{[3
]}

Labow, Daniel M. ^{[6
]}

Taouli, Bachir ^{[1
,3
]}

机构：

[1] Icahn Sch Med Mt Sinai, BioMed Engn & Imaging Inst, 1470 Madison Ave, New York, NY 10029 USA

[2] Lausanne Univ Hosp CHUV, Dept Radiol, Lausanne, Switzerland

[3] Icahn Sch Med Mt Sinai, Dept Diagnost Mol & Intervent Radiol, New York, NY 10029 USA

[4] Rabin Med Ctr, Dept Surg, Petah Tiqwa, Israel

[5] NYU, Dept Radiol, Langone Med Ctr, 560 1St Ave, New York, NY 10016 USA

[6] Icahn Sch Med Mt Sinai, Dept Surg, Div Surg Oncol, New York, NY 10029 USA

来源：

ABDOMINAL RADIOLOGY | 2023年 / 48卷 / 12期

基金：

瑞士国家科学基金会;

关键词：

MRI; FDG; PET; Peritoneal carcinomatosis; Diffusion; HYPERTHERMIC INTRAPERITONEAL CHEMOTHERAPY; CANCER INDEX PCI; ADVANCED OVARIAN-CANCER; SYSTEMIC CHEMOTHERAPY; CYTOREDUCTIVE SURGERY; COMPUTED-TOMOGRAPHY; RANDOMIZED-TRIAL; PREDICT; MRI; CT;

D O I：

10.1007/s00261-022-03703-1

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Purpose To assess the diagnostic performance of FDG-PET/MRI for the preoperative diagnosis and staging of peritoneal carcinomatosis (PC) using surgical Sugarbaker's PC index (PCI) as the reference in a multireader pilot study. Methods Fourteen adult patients (M/F: 3/11, mean age: 57 +/- 12 year) with PC were prospectively included in this single-center study. Patients underwent FDG-PET/MRI prior to surgery (mean delay: 14 d, range: 1-63 d). Images were reviewed independently by 2 abdominal radiologists and 2 nuclear medicine physicians. The radiologists assessed contrast-enhanced abdominal MR images, while the nuclear medicine physicians assessed PET images fused with T2-weighted images. The abdomen was divided in 13 regions, scored from 0 to 3. A hybrid FDG-PET/MRI radiological PCI was created by combining the study data. Radiological PCI was compared to the surgical PCI on a per-patient and per-region basis. Inter-reader agreement was evaluated. Results Mean surgical PCI was 10 +/- 8 (range: 0-24). Inter-reader agreement was almost perfect for all sets for radiologic PCI (Kappa: 0.81-0.98). PCI scores for all reading sets significantly correlated with the surgical PCI score (r range: 0.57-0.74, p range: < 0.001-0.003). Pooled per-patient sensitivity, specificity, and accuracy were 75%/50%/71.4% for MRI, 66.7%/50%/64.3% for FDG-PET, and 91.7%/50%/85.7% for FDG-PET/MRI, without significant difference (p value range 0.13-1). FDG-PET/MRI achieved 100% sensitivity and 100% specificity for a cutoff PCI of 20. Per-region sensitivity and accuracy were lower: 37%/61.8% for MRI, 17.8%/64.3% for FDG-PET, and 52.7%/60.4% for FDG-PET/MRI, with significantly higher sensitivity for FDG-PET/MRI. Per-region specificity was higher for FDG-PET (95%) compared to MRI (78.4%) and FDG-PET/MRI (66.5%). Conclusion FDG-PET/MRI achieved an excellent diagnostic accuracy per-patient and weaker performance per-region for detection of PC. The added value of PET/MRI compared to MRI and FDG-PET remains to be determined.

引用

页码：3634 / 3642

页数：9

共 34 条

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