HIV Reservoirs and Treatment Strategies toward Curing HIV Infection

被引：10

作者：

Matsuda, Kouki ^{[1
,2
]}

Maeda, Kenji ^{[1
]}

机构：

[1] Kagoshima Univ, Joint Res Ctr Human Retrovirus Infect, Kagoshima 8908544, Japan

[2] Natl Ctr Global Hlth & Med, AIDS Clin Ctr, Tokyo 1628655, Japan

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 05期

关键词：

HIV; HIV reservoir; Shock and Kill; Block and Lock; HIV cure; latency-reversing agents; CD4(+) T-CELLS; HISTONE DEACETYLASE INHIBITOR; LATENT-VIRUS REACTIVATION; ANTIRETROVIRAL THERAPY; IN-VIVO; DIDEHYDRO-CORTISTATIN; PERSISTENCE; REPLICATION; ANTIBODIES; AIDS;

D O I：

10.3390/ijms25052621

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Combination antiretroviral therapy (cART) has significantly improved the prognosis of individuals living with human immunodeficiency virus (HIV). Acquired immunodeficiency syndrome has transformed from a fatal disease to a treatable chronic infection. Currently, effective and safe anti-HIV drugs are available. Although cART can reduce viral production in the body of the patient to below the detection limit, it cannot eliminate the HIV provirus integrated into the host cell genome; hence, the virus will be produced again after cART discontinuation. Therefore, research into a cure (or remission) for HIV has been widely conducted. In this review, we focus on drug development targeting cells latently infected with HIV and assess the progress including our current studies, particularly in terms of the "Shock and Kill", and "Block and Lock" strategies.

引用

页数：14

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