The Omics Dashboard for Interactive Exploration of Metabolomics and Multi-Omics Data

被引:3
|
作者
Paley, Suzanne [1 ]
Karp, Peter D. [1 ]
机构
[1] SRI Int, Bioinformat Res Grp, Menlo Pk, CA 94025 USA
基金
美国国家科学基金会;
关键词
metabolomics; multi-omics; systems biology; data visualization;
D O I
10.3390/metabo14010065
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The Omics Dashboard is a software tool for interactive exploration and analysis of metabolomics, transcriptomics, proteomics, and multi-omics datasets. Organized as a hierarchy of cellular systems, the Dashboard at its highest level contains graphical panels for the full range of cellular systems, including biosynthesis, energy metabolism, and response to stimulus. Thus, the Dashboard top level surveys the state of the cell across a broad range of key systems in a single screen. Each Dashboard panel contains a series of X-Y plots depicting the aggregated omics data values relevant to different subsystems of that panel, e.g., subsystems within the biosynthesis panel include amino acid biosynthesis, carbohydrate biosynthesis and cofactor biosynthesis. Users can interactively drill down to focus in on successively lower-level subsystems of interest. In this article, we present for the first time the metabolomics analysis capabilities of the Omics Dashboard, along with significant new extensions to better accommodate metabolomics datasets, enable analysis and visualization of multi-omics datasets, and provide new data-filtering options.
引用
收藏
页数:13
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