Metal-Phenolic Network with Pd Nanoparticle Nodes Synergizes Oxidase-Like and Photothermal Properties to Eradicate Oral Polymicrobial Biofilm-Associated Infections

被引:54
作者
Chen, Lei [1 ,2 ]
Peng, Mengna [1 ]
Li, Huaping [1 ]
Zhou, Jianan [3 ]
He, Wei [3 ]
Hu, Rongdang [3 ]
Ye, Fangfu [1 ]
Li, Yuanfeng [1 ,4 ]
Shi, Linqi [5 ]
Liu, Yong [1 ]
机构
[1] Univ Chinese Acad Sci, Wenzhou Med Univ, Affiliated Hosp 1, Wenzhou Inst,Joint Ctr Translat Med, Wenzhou 325001, Zhejiang, Peoples R China
[2] Univ Chinese Acad Sci, Coll Mat Sci & Optoelect Technol, Ctr Mat Sci & Optoelect Engn, Beijing 100049, Peoples R China
[3] Wenzhou Med Univ, Sch & Hosp Stomatol, Dept Orthodont, Wenzhou 325027, Zhejiang, Peoples R China
[4] Wenzhou Med Univ, Affiliated Hosp 1, Translat Med Lab, Wenzhou 325035, Zhejiang, Peoples R China
[5] Nankai Univ, Coll Chem, Inst Polymer Chem, Minist Educ,Key Lab Funct Polymer Mat, Tianjin 300071, Peoples R China
基金
中国国家自然科学基金; 中国博士后科学基金;
关键词
biofilm eradication; combination therapy; lignin; photothermal therapy; reactive oxygen species;
D O I
10.1002/adma.202306376
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Designing an effective treatment strategy to combat oral diseases caused by complex polymicrobial biofilms remains a great challenge. Herein, a series of metal-phenolic network with Pd nanoparticle nodes using polyphenols as stabilizers and reducing agents is constructed. Among them, sulfonated lignin-Pd (SLS-Pd) with ultrafine size palladium nanoparticles and broadband near infrared absorption exhibit excellent oxidase-like activity and stable photothermal effect. In vitro experiments demonstrate that the superoxide radical generated by SLS-Pd oxidase-like activity exhibits selective antibacterial effects, while its photothermal effect induced hyperthermia exhibits potent antifungal properties. This difference is further elucidated by RNA-sequencing analysis and all-atom simulation. Moreover, the SLS-Pd-mediated synergistic antimicrobial system exhibits remarkable efficacy in combating various biofilms and polymicrobial biofilms. By establishing a root canal model and an oropharyngeal candidiasis model, the feasibility of the synergistic antimicrobial system in treating oral biofilm-related infections is further validated. This system provides a promising therapeutic approach for polymicrobial biofilm-associated infections in the oral cavity. A polyphenol-palladium network with excellent oxidase-like activity and photothermal effect is constructed. The reactive oxygen species treatment mediated by the oxidase-like activity of the network exhibits selective antibacterial effects, while its photothermal effect-induced hyperthermia possesses potent antifungal properties. Moreover, synergistic antimicrobial systems mediated by the network exhibit remarkable efficacy in combating various biofilms and polymicrobial biofilms, which can be used to treat oral biofilm-associated infections.image
引用
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页数:15
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