Total neoadjuvant therapy in oesophageal and gastro-oesophageal junctional adenocarcinoma

被引：5

作者：

Clements, Hollie A. ^{[1
,2
]}

Underwood, Tim J. ^{[3
]}

Petty, Russell D. ^{[1
,2
,4
,5
]}

机构：

[1] Univ Dundee, Ninewells Hosp, Div Mol & Clin Med, Dundee, Scotland

[2] Univ Dundee, Med Sch, Dundee, Scotland

[3] Univ Southampton, Univ Hosp Southampton NHS Fdn Trust, Sch Canc Sci, Southampton, England

[4] NHS Tayside, Ninewells Hosp, Tayside Canc Ctr, Dundee, Scotland

[5] NHS Tayside, Med Sch, Dundee, Scotland

来源：

BRITISH JOURNAL OF CANCER | 2024年 / 130卷 / 01期

关键词：

ADVANCED RECTAL-CANCER; PEMBROLIZUMAB PLUS CHEMOTHERAPY; LOCALLY ADVANCED ESOPHAGEAL; PHASE-III TRIAL; PREOPERATIVE CHEMOTHERAPY; ADJUVANT CHEMOTHERAPY; OPEN-LABEL; GASTRIC-CANCER; PERIOPERATIVE CHEMOTHERAPY; IMPROVED SURVIVAL;

D O I：

10.1038/s41416-023-02458-w

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Adenocarcinoma of the oesophagus and gastro-oesophageal junction represent a large burden of cancer death in the Western World with an increasing incidence. In the past two decades, the overall survival of patients on a potentially curative treatment pathway has more than doubled due to the addition of perioperative oncological therapies to surgery. However, patients often fail to respond to oncological treatment or struggle to complete their treatment after surgery. In this review, we discuss the current evidence for total neoadjuvant therapy and options for assessment of treatment response.

引用

页码：9 / 18

页数：10

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