Insights into COVID-19: Perspectives on Drug Remedies and Host Cell Responses

被引：3

作者：

Awad, Ahmed M. ^{[1
]}

Hansen, Kamryn ^{[1
]}

Del Rio, Diana ^{[1
]}

Flores, Derek ^{[1
]}

Barghash, Reham F. ^{[2
]}

Kakkola, Laura ^{[3
]}

Julkunen, Ilkka ^{[3
,4
]}

Awad, Kareem ^{[3
,5
]}

机构：

[1] Calif State Univ Channel Isl, Dept Chem, Camarillo, CA 93012 USA

[2] Inst Chem Ind Res, Natl Res Ctr, Cairo 12622, Egypt

[3] Univ Turku, Inst Biomed, Fac Med, Turku 20014, Finland

[4] Turku Univ Hosp, Clin Microbiol, Turku 20521, Finland

[5] Natl Res Ctr, Inst Pharmaceut & Drug Ind Res, Dept Therapeut Chem, Cairo 12622, Egypt

来源：

BIOMOLECULES | 2023年 / 13卷 / 10期

关键词：

coronavirus; COVID-19; target cell responses; drug design; nucleoside analogs; ACE2; RESPIRATORY SYNDROME CORONAVIRUS; VIRAL DISEASES; EBOLA-VIRUS; MERS-COV; SARS-COV-2; SARS; INFECTION; PATHOGENESIS; RIBAVIRIN; EFFICACY;

D O I：

10.3390/biom13101452

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In light of the COVID-19 global pandemic caused by SARS-CoV-2, ongoing research has centered on minimizing viral spread either by stopping viral entry or inhibiting viral replication. Repurposing antiviral drugs, typically nucleoside analogs, has proven successful at inhibiting virus replication. This review summarizes current information regarding coronavirus classification and characterization and presents the broad clinical consequences of SARS-CoV-2 activation of the angiotensin-converting enzyme 2 (ACE2) receptor expressed in different human cell types. It provides publicly available knowledge on the chemical nature of proposed therapeutics and their target biomolecules to assist in the identification of potentially new drugs for the treatment of SARS-CoV-2 infection.

引用

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