Adipocyte Regulation of Insulin Sensitivity and the Risk of Type 2 Diabetes

被引：44
作者：
Santoro, Anna
Kahn, Barbara B.
机构：
[1] Beth Israel Deaconess Med Ctr, Div Endocrinol Diabet & Metab, Dept Med, Boston, MA USA
[2] Harvard Med Sch, Boston, MA USA
来源：
NEW ENGLAND JOURNAL OF MEDICINE | 2023年 / 388卷 / 22期
关键词：
FATTY-ACID ESTERS; BINDING-PROTEIN; 4; ADIPOSE TRIGLYCERIDE LIPASE; LIPID STORAGE DISEASE; DE-NOVO LIPOGENESIS; TISSUE INFLAMMATION; RESISTANCE; RETINOL-BINDING-PROTEIN-4; MECHANISMS; OBESITY;
D O I：
10.1056/NEJMra2216691
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Adipose Tissue and Insulin Sensitivity Adipose tissue glucose transport and GLUT4 levels regulate systemic insulin sensitivity and whole-body energy balance, which have implications for the pathogenesis and treatment of obesity and diabetes. © 2023 Massachusetts Medical Society.
引用
收藏
页码：2071 / 2085
页数：15
相关论文
共 92 条
[11]   Association of Retinol-Binding Protein-4 (RBP4) with Lipid Parameters in Obese Women [J].
Broch, Montserrat ;
Gomez, Jose Manuel ;
Auguet, Ma Teresa ;
Vilarrasa, Nuria ;
Pastor, Rosa ;
Elio, Inaki ;
Olona, Montserrat ;
Garcia-Espana, Antonio ;
Richart, Cristobal .
OBESITY SURGERY, 2010, 20 (09) :1258-1264
[12]  
Carvalho Eugenia, 2001, FASEB Journal, V15, P1101
[13]   Circulating retinol binding protein 4 levels in coronary artery disease: a systematic review and meta-analysis [J].
Chen, Hengying ;
Zhang, Jiaying ;
Lai, Jiayu ;
Zhou, Yingyu ;
Lin, Xiaoping ;
Deng, Guifang ;
Zhang, Zheqing ;
Li, Liping .
LIPIDS IN HEALTH AND DISEASE, 2021, 20 (01)
[14]   Reassessing Human Adipose Tissue [J].
Cypess, Aaron M. .
NEW ENGLAND JOURNAL OF MEDICINE, 2022, 386 (08) :768-779
[15]   PAHSAs reduce cellular senescence and protect pancreatic beta cells from metabolic stress through regulation of Mdm2/p53 [J].
de Celis, Maria F. Rubin ;
Garcia-Martin, Ruben ;
Syed, Ismail ;
Lee, Jennifer ;
Aguayo-Mazzucato, Cristina ;
Bonner-Weir, Susan ;
Kahn, Barbara B. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2022, 119 (47)
[16]   Determination of Major Endogenous FAHFAs in Healthy Human Circulation: The Correlations with Several Circulating Cardiovascular-Related Biomarkers and Anti-Inflammatory Effects on RAW 264.7 Cells [J].
Dongoran, Rachmad Anres ;
Lin, Tsung-Jen ;
Byekyet, Akhsholphan ;
Tang, Sheau-Chung ;
Yang, Jen-Hung ;
Liu, Chin-Hung .
BIOMOLECULES, 2020, 10 (12) :1-17
[17]   The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes [J].
Drucker, Daniel J. ;
Nauck, Michael A. .
LANCET, 2006, 368 (9548) :1696-1705
[18]   Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1 [J].
Drucker, Daniel J. .
CELL METABOLISM, 2018, 27 (04) :740-756
[19]   Insulin's direct hepatic effect explains the inhibition of glucose production caused by insulin secretion [J].
Edgerton, Dale S. ;
Kraft, Guillaume ;
Smith, Marta ;
Farmer, Ben ;
Williams, Phillip E. ;
Coate, Katie C. ;
Printz, Richard L. ;
O'Brien, Richard M. ;
Cherrington, Alan D. .
JCI INSIGHT, 2017, 2 (06)
[20]   De novo lipogenesis in human fat and liver is linked to ChREBP-β and metabolic health [J].
Eissing, Leah ;
Scherer, Thomas ;
Toedter, Klaus ;
Knippschild, Uwe ;
Greve, Jan Willem ;
Buurman, Wim A. ;
Pinnschmidt, Hans O. ;
Rensen, Sander S. ;
Wolf, Anna M. ;
Bartelt, Alexander ;
Heeren, Joerg ;
Buettner, Christoph ;
Scheja, Ludger .
NATURE COMMUNICATIONS, 2013, 4
12345678910