Adipocyte Regulation of Insulin Sensitivity and the Risk of Type 2 Diabetes

被引：44
作者：
Santoro, Anna
Kahn, Barbara B.
机构：
[1] Beth Israel Deaconess Med Ctr, Div Endocrinol Diabet & Metab, Dept Med, Boston, MA USA
[2] Harvard Med Sch, Boston, MA USA
来源：
NEW ENGLAND JOURNAL OF MEDICINE | 2023年 / 388卷 / 22期
关键词：
FATTY-ACID ESTERS; BINDING-PROTEIN; 4; ADIPOSE TRIGLYCERIDE LIPASE; LIPID STORAGE DISEASE; DE-NOVO LIPOGENESIS; TISSUE INFLAMMATION; RESISTANCE; RETINOL-BINDING-PROTEIN-4; MECHANISMS; OBESITY;
D O I：
10.1056/NEJMra2216691
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Adipose Tissue and Insulin Sensitivity Adipose tissue glucose transport and GLUT4 levels regulate systemic insulin sensitivity and whole-body energy balance, which have implications for the pathogenesis and treatment of obesity and diabetes. © 2023 Massachusetts Medical Society.
引用
收藏
页码：2071 / 2085
页数：15
相关论文
共 92 条
[1]   Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver [J].
Abel, ED ;
Peroni, O ;
Kim, JK ;
Kim, YB ;
Boss, O ;
Hadro, E ;
Minnemann, T ;
Shulman, GI ;
Kahn, BB .
NATURE, 2001, 409 (6821) :729-733
[2]   Distinct biological activities of isomers from several families of branched fatty acid esters of hydroxy fatty acids (FAHFAs) [J].
Aryal, Pratik ;
Syed, Ismail ;
Lee, Jennifer ;
Patel, Rucha ;
Nelson, Andrew T. ;
Siegel, Dionicio ;
Saghatelian, Alan ;
Kahn, Barbara B. .
JOURNAL OF LIPID RESEARCH, 2021, 62
[3]   Microfluidic-enabled quantitative measurements of insulin release dynamics from single islets of Langerhans in response to 5-palmitic acid hydroxy stearic acid [J].
Bandak, Basel ;
Yi, Lian ;
Roper, Michael G. .
LAB ON A CHIP, 2018, 18 (18) :2873-2882
[4]   Long-term high intake of 9-PAHPA or 9-OAHPA increases basal metabolism and insulin sensitivity but disrupts liver homeostasis in healthy mice [J].
Benlebna, Melha ;
Balas, Laurence ;
Bonafos, Beatrice ;
Pessemesse, Laurence ;
Vigor, Claire ;
Grober, Jacques ;
Bernex, Florence ;
Fouret, Gilles ;
Paluchova, Veronika ;
Gaillet, Sylvie ;
Landrier, Jean Francois ;
Kuda, Ondrej ;
Durand, Thierry ;
Coudray, Charles ;
Casas, Francois ;
Feillet-Coudray, Christine .
JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2020, 79
[5]   Cognitive decline and dementia in diabetes mellitus: mechanisms and clinical implications [J].
Biessels, Geert Jan ;
Despa, Florin .
NATURE REVIEWS ENDOCRINOLOGY, 2018, 14 (10) :591-604
[6]  
Bliss M., 1982, The discovery of insulin
[7]   Distinct roles of adipose triglyceride lipase and hormone-sensitive lipase in the catabolism of triacylglycerol estolides [J].
Brejchova, Kristyna ;
Radner, Franz Peter Walter ;
Balas, Laurence ;
Paluchova, Veronika ;
Cajka, Tomas ;
Chodounska, Hana ;
Kudova, Eva ;
Schratter, Margarita ;
Schreiber, Renate ;
Durand, Thierry ;
Zechner, Rudolf ;
Kuda, Ondrej .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 118 (02)
[8]   Understanding FAHFAs: From structure to metabolic regulation [J].
Brejchova, Kristyna ;
Balas, Laurence ;
Paluchova, Veronika ;
Brezinova, Marie ;
Durand, Thierry ;
Kuda, Ondrej .
PROGRESS IN LIPID RESEARCH, 2020, 79
[9]   Exercise training induces insulin-sensitizing PAHSAs in adipose tissue of elderly women [J].
Brezinova, Marie ;
Cajka, Tomas ;
Oseeva, Marina ;
Stepan, Marek ;
Dadova, Klara ;
Rossmeislova, Lenka ;
Matous, Milos ;
Siklova, Michaela ;
Rossmeisl, Martin ;
Kuda, Ondrej .
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2020, 1865 (02)
[10]   Levels of palmitic acid ester of hydroxystearic acid (PAHSA) are reduced in the breast milk of obese mothers [J].
Brezinova, Marie ;
Kuda, Ondrej ;
Hansikova, Jana ;
Rombaldova, Martina ;
Balas, Laurence ;
Bardova, Kristina ;
Durand, Thierry ;
Rossmeisl, Martin ;
Cerna, Marcela ;
Stranak, Zbynek ;
Kopecky, Jan .
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2018, 1863 (02) :126-131
12345678910