Effect of polymorphisms CYP17 (rs743572), SOD2 (rs4880) and CAT (rs1001179) on hormonal profile and redox status of blood serum and follicular fluid in patients with polycystic ovary syndrome

Polycystic Ovary syndrome (PCOS) is a heterogeneous disease, and its pathophysiology is quite complex. Hyperandrogenism, insulin resistance and recently oxidative stress are considered the main causes of initiating and developing the disease, they act synergistically and stimulate each other in a vicious cycle. Our study was aimed at investigation the relationship between polymorphisms in the genes CYP17 (rs743572), SOD2 (rs4880), and CAT (rs1001179) and the risk of PCOS. As well as to establish the relationship of polymorphic markers with the development of oxidative stress and a violation of the hormonal profile of blood serum and follicular fluid in PCOS. Our genotyping analysis showed that polymorphisms in CYP17 (rs743572) and SOD2 (rs4880), but not CAT (rs1001179) might be risk factors for PCOS development, since the presence of at least one mutant allele of rs743572 or rs4880 increases the risk of developing the syndrome. We found an association between LH and estradiol levels in the serum and the polymorphic variants of CYP17 (rs743572) and SOD2 (rs4880), respectively in PCOS patients. Furthermore, our results demonstrate a significant increase in oxidative stress with a decrease in SOD and CAT activity in the follicular fluid of PCOS patients.