Cu/Ag-Mediated One-Pot Enantioselective Synthesis of Fully Decorated 1,2,3-Triazolo[1,5-a]pyrazines

被引：10

作者：

Geng, Zi-Qi ^{[1
]}

Zhao, Chunhui ^{[1
]}

Qian, Hao-Dong ^{[1
]}

Li, Si-Jia ^{[1
]}

Peng, Hao ^{[1
]}

Xu, Hao ^{[1
]}

机构：

[1] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol &, CCNU uOttawa Joint Res Ctr,Key Lab Pesticides & Ch, 152 Luoyu Rd, Wuhan 430079, Peoples R China

来源：

ORGANIC LETTERS | 2023年 / 25卷 / 24期

基金：

中国国家自然科学基金;

关键词：

CLICK REACTION; CYCLOADDITION; AZIDE; BENZODIAZEPINE; BINDING; ALKYNES; ACCESS; ESTERS;

D O I：

10.1021/acs.orglett.3c01524

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Thesynthesis of chiral triazole-fused pyrazine scaffolds fromreadily available substrates in a step-economical asymmetric catalyticway is highly appealing. We herein report that an efficient Cu/Agrelay catalyzed protocol employing cascade asymmetric propargylicamination, hydroazidation, and [3 + 2] cycloaddition reaction withhigh efficiency to access the target enantioenriched 1,2,3-triazolo[1,5-a]pyrazine has been accomplished by applying a novel N,N,P-ligand. The one-potreaction of three components exhibits high functional group tolerance,excellent enantioselectivities, and a broad substrate scope with readilyavailable starting materials.

引用

收藏

页码：4504 / 4509

页数：6

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