Metformin suppresses tumor immune evasion through downregulation of PD-L1 expression in cancer cells and PD-1 expression in NK cells and T cells

被引:1
|
作者
Park, Su Hwan
Lee, Jong-Ho
机构
关键词
D O I
10.1158/1538-7445.AM2023-6636
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
6636
引用
收藏
页数:2
相关论文
共 50 条
  • [21] Assessment of PD-L1 Expression on Circulating Tumor Cells for Predicting Clinical Outcomes in Patients with Cancer Receiving PD-1/PD-L1 Blockade Therapies
    Tan, Zhaoli
    Yue, Chunyan
    Ji, Shoujian
    Zhao, Chuanhua
    Jia, Ru
    Zhang, Yun
    Liu, Rongrui
    Li, Da
    Yu, Qian
    Li, Ping
    Hu, Zhiyuan
    Yang, Yanlian
    Xu, Jianming
    ONCOLOGIST, 2021, : e2227 - e2238
  • [22] Infiltration of CD8 T Cells and Expression of PD-1 and PD-L1 in Synovial Sarcoma
    Nowicki, Theodore S.
    Akiyama, Ryan
    Huang, Rong Rong
    Shintaku, I. Peter
    Wang, Xiaoyan
    Tumeh, Paul C.
    Singh, Arun
    Chmielowski, Bartosz
    Denny, Christopher
    Federman, Noah
    Ribas, Antoni
    CANCER IMMUNOLOGY RESEARCH, 2017, 5 (02) : 118 - 126
  • [23] Contribution of NK cells to immunotherapy mediated by PD-1/PD-L1 blockade
    Hsu, Joy
    Hodgins, Jonathan J.
    Marathe, Malvika
    Nicolai, Chris J.
    Bourgeois-Daigneault, Marie-Claude
    Trevino, Troy N.
    Azimi, Camillia S.
    Scheer, Amit K.
    Randolph, Haley E.
    Thompson, Thornton W.
    Zhang, Lily
    Iannello, Alexandre
    Mathur, Nikhita
    Jardine, Karen E.
    Kirn, Georgia A.
    Bell, John C.
    McBurney, Michael W.
    Raulet, David H.
    Ardolino, Michele
    JOURNAL OF CLINICAL INVESTIGATION, 2018, 128 (10): : 4654 - 4668
  • [24] Loss of VGLL4 suppresses tumor PD-L1 expression and immune evasion
    Wu, Ailing
    Wu, Qingzhe
    Deng, Yujie
    Liu, Yuning
    Lu, Jinqiu
    Liu, Liansheng
    Li, Xiaoling
    Liao, Cheng
    Zhao, Bin
    Song, Hai
    EMBO JOURNAL, 2019, 38 (01):
  • [25] Changes in expression of PD-L1 on peripheral T cells in patients with melanoma and lung cancer treated with PD-1 inhibitors
    Sarah J. Dart
    Alistair M. Cook
    Michael J. Millward
    Alison M. McDonnell
    Wee L. Chin
    Muhammad U. Hakeem
    Tarek M. Meniawy
    Samantha E. Bowyer
    Scientific Reports, 11
  • [26] PD-L1, PD-L2 and PD-1 expression in metastatic melanoma: Correlation with tumor-infiltrating immune cells and clinical outcome
    Obeid, Joseph M.
    Erdag, Gulsun
    Smolkin, Mark E.
    Deacon, Donna H.
    Patterson, James W.
    Chen, Leiping
    Bullock, Timothy N.
    Slingluff, Craig L.
    ONCOIMMUNOLOGY, 2016, 5 (11):
  • [27] Does PD-L1 Positivity in Inflammatory Cells Correlate with PD-L1 Expression in Tumor Cells in Colorectal Adenocarcinoma?
    Broadwater, D. R.
    Williams, G.
    Messersmith, L.
    Brady, R.
    AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2020, 154 : S157 - S157
  • [28] Changes in expression of PD-L1 on peripheral T cells in patients with melanoma and lung cancer treated with PD-1 inhibitors
    Dart, Sarah J.
    Cook, Alistair M.
    Millward, Michael J.
    McDonnell, Alison M.
    Chin, Wee L.
    Hakeem, Muhammad U.
    Meniawy, Tarek M.
    Bowyer, Samantha E.
    SCIENTIFIC REPORTS, 2021, 11 (01)
  • [29] Immune evasion via PD-1/PD-L1 on NK cells and monocyte/macrophages is more prominent in Hodgkin lymphoma than DLBCL
    Vari, Frank
    Arpon, David
    Keane, Colm
    Hertzberg, Mark S.
    Talaulikar, Dipti
    Jain, Sanjiv
    Cui, Qingyan
    Han, Erica
    Tobin, Josh
    Bird, Robert
    Cross, Donna
    Hernandez, Annette
    Gould, Clare
    Birch, Simone
    Gandhi, Maher K.
    BLOOD, 2018, 131 (16) : 1809 - 1819
  • [30] PD-1 AND PD-L1 EXPRESSION IN OVARIAN CANCER
    Wieser, V.
    Gaugg, I.
    Fleischer, M.
    Fiegl, H.
    Marth, C.
    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2016, 26 : 64 - 64