Endoplasmic reticulum-associated degradation shown to regulate innate immunity

被引：0

作者：

Ji, Yewei ^{[1
]}

Qi, Ling ^{[2
]}

机构：

[1] Zhejiang Univ, Sch Med, Hangzhou, Peoples R China

[2] Univ Michigan, Med Sch, Ann Arbor, MI USA

来源：

NATURE CELL BIOLOGY | 2023年 / 25卷 / 05期

关键词：

D O I：

10.1038/s41556-023-01139-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The SEL1L-HRD1 endoplasmic reticulum-associated degradation pathway negatively regulates STING-mediated innate immunity by ubiquitinating and targeting STING for proteasomal degradation, thereby limiting its activation.

引用

页码：641 / 642

页数：2

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