Endoplasmic reticulum-associated degradation shown to regulate innate immunity

被引：0
|
作者：
Ji, Yewei [1 ]
Qi, Ling [2 ]
机构：
[1] Zhejiang Univ, Sch Med, Hangzhou, Peoples R China
[2] Univ Michigan, Med Sch, Ann Arbor, MI USA
来源：
NATURE CELL BIOLOGY | 2023年 / 25卷 / 05期
关键词：
D O I：
10.1038/s41556-023-01139-3
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The SEL1L-HRD1 endoplasmic reticulum-associated degradation pathway negatively regulates STING-mediated innate immunity by ubiquitinating and targeting STING for proteasomal degradation, thereby limiting its activation.
引用
收藏
页码：641 / 642
页数：2
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