Nanoemulsions of Some Edible Oils and their Antimicrobial, Antioxidant, and Anti-hemolytic Activities

Plant oils have been applied for numerous purposes. Developing the composition of oils through nanotechnology has become a requirement, whether from a medical or industrial point of view. In this study, nanoemulsions (NEs) of olive and peanut oils were evaluated. GC-MS was used to determine the saturated and unsaturated fatty acids contents in both oils. Based on the area %, cis-8,11,14-eicosatrienoic acid (54.0%), myristic acid (30.7%), and arachidonic acid (23.1%) were the greatest constituents in peanut oil, while arachidonic acid (23.2%), cis-11,14,17-eicosatrienoic acid (22.7%), and cis-11-eicosenoic acid (11.4%) were the greatest constituents in olive oil. TEM examination indicated that the diameter of peanut oil NEs (14.6 nm) was less than that of olive oil NEs (24.5 nm). Olive oil and its NEs exhibited more antioxidant activity than peanut oil and its NEs had IC5o values of 158.6, 102.5, 435.1, and 291.5 pg/mL, respectively. Negligible hemolysis was observed using olive oil, unlike peanut oil, while hemolysis based olive oil NEs was increased compared with hemolysis based peanut oil NEs, particularly at high concentrations of 600 to 1000 pg/mL. Molecular docking investigation offered the structure -activity correlation and binding modes of cis-8,11,14-eicosatrienoic acid with Salmonella typhi (5ZXM) enzymes.