Exosomes based strategies for brain drug delivery

被引：129

作者：

Rehman, Fawad Ur ^{[1
,2
,3
]}

Liu, Yang ^{[1
,2
]}

Zheng, Meng ^{[1
,2
]}

Shi, Bingyang ^{[1
,2
,4
]}

机构：

[1] Henan Univ, Henan Macquire Int Joint Ctr Biomed Innovat, Sch Life Sci, JinMing Ave, Kaifeng 475004, Peoples R China

[2] Henan Univ, Sch Life Sci & Sch Pharm, Henan Key Lab Brain Targeted Bionanomed, Kaifeng 475004, Henan, Peoples R China

[3] Aga Khan Univ, Ctr Regenerat Med & Stem Cells Res, Stadium Rd, Karachi 74800, Pakistan

[4] Macquarie Univ, Dept Biomed Sci, Fac Med & Hlth Sci, Sydney, NSW 2109, Australia

来源：

BIOMATERIALS | 2023年 / 293卷

基金：

中国国家自然科学基金;

关键词：

Exosomes; Drug delivery; Neurodegenerative diseases; Glioma; Blood-brain barrier; MESENCHYMAL STEM-CELLS; EXTRACELLULAR VESICLES PROTECT; STROMAL CELLS; IN-VITRO; AMYLOID-BETA; ENGINEERING EXOSOMES; HUNTINGTONS-DISEASE; FUNCTIONAL RECOVERY; MONONUCLEAR-CELLS; MODEL;

D O I：

10.1016/j.biomaterials.2022.121949

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Exosome application has emerged as a promising nanotechnology discipline for various diseases therapeutics and diagnoses. Owing to the natural properties of efficient drug delivery, higher biocompatibility, facile traversing of physiological barriers, and subtle side effects, exosomes shorten their way to clinical translation. Exosomes are nanoscale membrane-bound vesicles primarily involved in intercellular communication and exhibit natural blood-brain barrier (BBB) traversing ability, which enables their application as drug delivery vehicles for brain diseases treatment. Herein, we highlight recent exosome-based drug delivery endeavors for neurodegenerative diseases and brain cancer therapy, summarize the obstacles and future directions in clinical translation.

引用

页数：18

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