Evaluation of the Levels of Selected Cytokines and Their Possible Influence on the Development of Cardiovascular and Pulmonary Complications in Patients after COVID-19

被引:0
作者
Stanjek-Cichoracka, Anita [1 ,2 ]
Niedziela, Jacek T. [3 ,4 ]
Laszewska, Anna [2 ]
Medrala, Zofia [3 ]
Nowowiejska-Wiewiora, Alicja [3 ]
Kaczmarski, Jacek [5 ]
Grzanka, Alicja [6 ]
Gasior, Mariusz [3 ,4 ]
机构
[1] Med Univ Silesia, Fac Pharmaceut Sci Sosnowiec, Dept Biophys, Jednosci 8, PL-41200 Sosnowiec, Poland
[2] Silesian Ctr Heart Dis, Lab Transplant Immunol, PL-41800 Zabrze, Poland
[3] Silesian Ctr Heart Dis, Dept Cardiol 3, PL-41800 Zabrze, Poland
[4] Med Univ Silesia, Fac Med Sci Zabrze, Dept Cardiol 3, PL-40752 Katowice, Poland
[5] Silesian Ctr Heart Dis, Dept Lab Diagnost Environm & Civilizat Dis, Sect Coagulat Disorders, PL-41800 Zabrze, Poland
[6] Med Univ Silesia, Fac Med Sci Zabrze, Dept Allergol, PL-40752 Katowice, Poland
来源
MEDICINA-LITHUANIA | 2024年 / 60卷 / 03期
关键词
cytokines; COVID-19; cardiovascular and pulmonary complications; Luminex; GROWTH-FACTOR; ASTHMA; MCP-1; VEGF; PDGF;
D O I
10.3390/medicina60030353
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background and Objectives: The aim of this study was to evaluate the levels of selected cytokines and their possible influence on the development of cardiovascular and pulmonary complications in patients hospitalized at the Silesian Centre for Heart Disease in Zabrze after having undergone COVID-19. Materials and methods: The study included 76 randomly selected patients from the SILCOVID-19 database. The median time from symptom onset to the study visit was 102 (86-118) days. The median age of the study group was 53 (44-60) years. Assays of a panel of 30 cytokines were carried out in the serum of patients on a Luminex100 platform using the Milliplex MAP kit from Merck KGaA Germany. Results: There were no statistically significant differences in most of the cytokines analyzed between patients with confirmed or excluded lung lesions or cardiac abnormalities. Additionally, no statistically significant differences in cytokine concentrations according to gender, age, comorbidity of diabetes, renal disease, hypertension, increased risk of thrombotic disease, or psychological disorders were demonstrated. There were high concentrations of cytokines such as platelet-derived growth actor-AA (PDGF-AA), monocyte chemoattractant protein-1 (MCP-1), monokine-induced gamma interferon (MIG), and vascular endothelial growth factor-A (VEGF-A). Conclusions: No direct impact of the dependencies between a panel of cytokines and the incidence of cardiovascular and pulmonary complications in patients hospitalized at the Silesian Centre for Heart Disease in Zabrze after having undergone COVID-19 was demonstrated. The demonstration of high levels of certain cytokines (PDGF-AA, VEGF, MIG, and IP10) that are of significance in the development of many lung diseases, as well as cytokines (MCP-1) that influence the aetiopathogenesis of cardiovascular diseases seems to be highly concerning in COVID-19 survivors. This group of patients should receive further monitoring of these cytokine levels and diagnostic imaging in order to detect more severe abnormalities as early as possible and administer appropriate therapy.
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页数:12
相关论文
共 33 条
[1]  
A, 2021, Clinical Case Definition of Post COVID-19 Condition by a Delphi Consensus
[2]   Long COVID and its cardiovascular implications: a call to action [J].
Al-Aly, Ziyad .
EUROPEAN HEART JOURNAL, 2023, 44 (47) :5001-5003
[3]  
[Anonymous], Post-COVID Conditions
[4]   Stimulation of HIF-1α, HIF-2α, and VEGF by prolyl 4-hydroxylase inhibition in human lung endothelial and epithelial cells [J].
Asikainen, TM ;
Ahmad, A ;
Schneider, BK ;
Ho, WB ;
Arend, M ;
Brenner, M ;
Günzler, V ;
White, CW .
FREE RADICAL BIOLOGY AND MEDICINE, 2005, 38 (08) :1002-1013
[5]   Clinical and immunological features of severe and moderate coronavirus disease 2019 [J].
Chen, Guang ;
Wu, Di ;
Guo, Wei ;
Cao, Yong ;
Huang, Da ;
Wang, Hongwu ;
Wang, Tao ;
Zhang, Xiaoyun ;
Chen, Huilong ;
Yu, Haijing ;
Zhang, Xiaoping ;
Zhang, Minxia ;
Wu, Shiji ;
Song, Jianxin ;
Chen, Tao ;
Han, Meifang ;
Li, Shusheng ;
Luo, Xiaoping ;
Zhao, Jianping ;
Ning, Qin .
JOURNAL OF CLINICAL INVESTIGATION, 2020, 130 (05) :2620-2629
[6]   Platelet-derived growth factors and their receptors: Structural and functional perspectives [J].
Chen, Po-Han ;
Chen, Xiaoyan ;
He, Xiaolin .
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2013, 1834 (10) :2176-2186
[7]   Clinicopathological Outlines of Post-COVID-19 Pulmonary Fibrosis Compared with Idiopathic Pulmonary Fibrosis [J].
Cirjaliu, Roxana-Elena ;
Deacu, Mariana ;
Gherghisan, Ioana ;
Marghescu, Angela Stefania ;
Enciu, Manuela ;
Baltatescu, Gabriela Izabela ;
Nicolau, Antonela Anca ;
Tofolean, Doina-Ecaterina ;
Arghir, Oana Cristina ;
Fildan, Ariadna-Petronela .
BIOMEDICINES, 2023, 11 (06)
[8]   Cognitive impairment in long-COVID and its association with persistent dysregulation in inflammatory markers [J].
Damiano, Rodolfo Furlan ;
Rocca, Cristiana Castanho de Almeida ;
Serafim, Antonio de Padua M. ;
Loftis, Jennifer ;
Talib, Leda Leme ;
Pan, Pedro Mario ;
Cunha-Neto, Edecio ;
Kalil, Jorge ;
de Castro, Gabriela Salim ;
Seelaender, Marilia F. ;
Guedes, Bruno K. ;
Marie, Suely K. Nagahashi ;
de Souza, Heraldo Possolo ;
Nitrini, Ricardo ;
Miguel, Euripedes Constantino ;
Busatto, Geraldo ;
Forlenza, Orestes, V .
FRONTIERS IN IMMUNOLOGY, 2023, 14
[9]   PDGF receptor signaling networks in normal and cancer cells [J].
Demoulin, Jean-Baptiste ;
Essaghir, Ahmed .
CYTOKINE & GROWTH FACTOR REVIEWS, 2014, 25 (03) :273-283
[10]   Cytokine signatures of end organ injury in COVID-19 [J].
Gomez-Escobar, Luis G. ;
Hoffman, Katherine L. ;
Choi, Justin J. ;
Borczuk, Alain ;
Salvatore, Steven ;
Alvarez-Mulett, Sergio L. ;
Galvan, Manuel D. ;
Zhao, Zhen ;
Racine-Brzostek, Sabrina E. ;
Yang, He S. ;
Stout-Delgado, Heather W. ;
Choi, Mary E. ;
Choi, Augustine M. K. ;
Cho, Soo Jung ;
Schenck, Edward J. .
SCIENTIFIC REPORTS, 2021, 11 (01)