New dammarane-type triterpenoids from the whole plant of Euphorbia hypericifolia

被引：2

作者：

Xu, Mengke ^{[1
]}

Liu, Jiacheng ^{[2
]}

Sun, Wenrui ^{[1
]}

Chen, Yutian ^{[3
]}

Wang, Mengyu ^{[1
]}

Zhou, Yangfan ^{[1
]}

机构：

[1] Zhengzhou Univ, Affiliated Hosp 1, Cardiovasc Ctr, Dept Cardiol,Henan Key Lab Hereditary Cardiovasc D, Zhengzhou, Peoples R China

[2] Zhengzhou Univ, Sch Basic Med Sci, Dept Pharmacol, Zhengzhou, Peoples R China

[3] Zhengzhou Univ, Affiliated Hosp 1, Dept Endovascular Surg, Zhengzhou, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2024年

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

Euphorbia hypericifolia; dammarane triterpenoid; tetracyclic triterpenoid; anti-platelet aggregation; ANTIPLATELET AGGREGATION ACTIVITY; TETRACYCLIC TRITERPENOIDS;

D O I：

10.1080/14786419.2024.2324106

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Euphorhypenoids A (1) and B (2), two new dammarane-type triterpenoids, along with four known tetracyclic triterpenoids (3-6), were isolated from the whole plant of Euphorbia hypericifolia. The structures of new compounds were mainly elucidated by a series of extensive spectroscopic methods, including HR-ESI-MS, NMR, IR, and UV. Compound 1 exhibited significant inhibitory effect on platelet aggregation at concentrations of 10 - 200 mu M. [GRAPHICAL ABSTRACT]

引用

页数：6

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