Four new pregnane C21 steroids isolated from the roots of Cynanchum auriculatum

被引：5

作者：

Fan, Yi-min ^{[1
,2
]}

Yi, Ping ^{[1
,2
]}

Jin, Jun ^{[1
,2
]}

Jian, Jun-you ^{[1
,2
]}

Gu, Wei ^{[1
,2
]}

Yuan, Chun-mao ^{[1
,2
]}

Hu, Zhan-xing ^{[1
,2
]}

Hao, Xiao-jiang ^{[1
,2
]}

Huang, Lie-jun ^{[1
,2
]}

机构：

[1] Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guiyang, Peoples R China

[2] Nat Prod Res Ctr Guizhou Prov, Guiyang, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2023年

基金：

中国国家自然科学基金;

关键词：

Cynanchum auriculatum; steroids; spectroscopic analyses; cytotoxic activities; ASCLEPIADACEAE PLANTS; CONSTITUENTS; GLYCOSIDES; COMPONENT;

D O I：

10.1080/14786419.2023.2294112

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Four new steroids cynansteroid G-I (1-3) and cynansteroid K (4), a new natural product 5,6-deacidizingcaudatin (5), and a known compound glycocaudatin (6), were isolated from the roots of Cynanchum auriculatum. The structures of new compounds were identified by comprehensive spectroscopic analyses, including NMR, HRESI-MS, ECD, UV, and IR spectral data. The cytotoxic activities of all the isolates against two human tumour cell lines (COLO-205 and BGC-823) were screened, unfortunately, which were weaker than positive control.

引用

收藏

页码：2181 / 2186

页数：6

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