Human Ductal Carcinoma In Situ: Advances and Future Perspectives

被引：3

作者：

Behbod, Fariba ^{[1
]}

Chen, Jennifer H. ^{[2
]}

Thompson, Alastair ^{[3
]}

机构：

[1] Univ Kansas, Med Ctr, Dept Pathol & Lab Med, MS 3045, Kansas City, KS 66160 USA

[2] Baylor Coll Med, Michael E DeBakey Dept Surg, Houston, TX 77030 USA

[3] Baylor Coll Med, Lester & Sue Smith Breast Ctr, Dan L Duncan Comprehens Canc Ctr, Sect Breast Surg, Houston, TX 77030 USA

来源：

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE | 2023年 / 13卷 / 10期

关键词：

COMPARATIVE GENOMIC HYBRIDIZATION; INVASIVE BREAST-CANCER; MYOEPITHELIAL CELL; RISK-FACTORS; TUMOR-CELLS; PHASE-III; PROGRESSION; EXPRESSION; CAVEOLIN-1; GRADE;

D O I：

10.1101/cshperspect.a041319

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Due to widespread adoption of screening mammography, there has been a significant increase in new diagnoses of ductal carcinoma in situ (DCIS). However, DCIS outcomes remain unclear. A large fraction of human DCIS (>50%) may not need the multimodality treatment options currently offered to all DCIS patients. More importantly, while we may be overtreating many, we cannot identify those most at risk of invasion or metastasis following a DCIS diagnosis. This review summarizes the studies that have furthered our understanding of DCIS pathology and mechanisms of invasive progression by using advanced technologies including spatial genomics, transcriptomics, and multiplex proteomics. This review also highlights a need for rethinking DCIS with a more focused view on epithelial states and programs and their cross talk with the microenvironment.

引用

页数：22

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