Synthesis and Molecular Docking Analysis of New Thiazo-isoindolinedione Hybrids as Potential Inhibitors of the SARS-CoV-2 Main Protease

被引：3

作者：

Shaaban, Saad ^{[1
,2
]}

Al-Karmalawy, Ahmed A. ^{[3
]}

Alhamzani, Abdulrahman G. ^{[4
]}

Abou-Krisha, Mortaga M. ^{[4
,5
]}

Al-Qudah, Mahmoud A. ^{[4
,6
]}

Yousef, Tarek A. ^{[4
,7
]}

机构：

[1] King Faisal Univ, Dept Chem, Coll Sci, Al Hasa 31982, Saudi Arabia

[2] Mansoura Univ, Dept Chem, Fac Sci, Mansoura 35516, Egypt

[3] Ahram Canadian Univ, Dept, Fac Pharm, Giza 12566, Egypt

[4] Imam Mohammad Ibn Saud Islam Univ, Dept Chem, Coll Sci, Riyadh 11623, Saudi Arabia

[5] Yarmouk Univ, Dept Chem, Fac Sci, POB 566, Irbid 21163, Jordan

[6] South Valley Univ, Dept Chem, Qena 83523, Egypt

[7] Minist Justice, Dept Toxic & Narcot Drug, Forens Med, Medicolegal Org,Mansoura Lab, Cairo, Egypt

来源：

ORIENTAL JOURNAL OF CHEMISTRY | 2023年 / 39卷 / 04期

关键词：

Condensation; COVID-19; Isoindolinedione; Thiazolidinedione; Molecular docking;

D O I：

10.13005/ojc/390412

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Herein, we report the synthesis of novel thiazo-isoindolinedione derivatives in excellent yields (up to 92%) from the reaction of thiazolidinedione and isoindoline-dione. The structures of the novel compounds were elucidated by H-1-, C-13-NMR, and MS analyses. Furthermore, molecular docking analysis was performed to study the potential inhibition of the SARS-CoV-2 main protease (M-pro) by the new thiazo-isoindolinediones. The present study revealed that the new thiazo-isoindolinediones could inhibit the Mpro and represent a promising platform for the experimental development of new antiviral drugs based on thiazo-isoindolinedione scaffolds.

引用

页码：913 / 918

页数：6

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