Iron-Catalyzed Oxyphosphorylation of Styrenes to Access β-Ketophosphonates and α, β-Unsaturated Ketones

被引：4

作者：

Zhao, Yukun ^{[1
]}

Xu, Jingwen ^{[1
]}

Chen, Hongbing ^{[1
]}

Xia, Yi ^{[1
]}

Hu, Lin ^{[1
,2
]}

机构：

[1] Chongqing Univ, Sch Pharmaceut Sci, Chongqing Key Lab Nat Prod Synth & Drug Res, Chongqing 401331, Peoples R China

[2] Peking Univ, Shenzhen Grad Sch, State Key Lab Chem Oncogen, Key Lab Chem Genom, Shenzhen 518055, Guangdong, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2023年 / 365卷 / 19期

关键词：

Iron; Aerobic oxidation; beta-Ketophosphonates; alpha; beta-Unsaturated carbonyl compounds; AEROBIC OXYPHOSPHORYLATION; CARBONYL-COMPOUNDS; PHOSPHONATES; ACIDS; ALKYNES;

D O I：

10.1002/adsc.202300733

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The first iron-catalyzed oxophosphorylation of styrene derivatives with dialkyl H-phosphonates under open air conditions is developed, which generates a range of previously underexplored asubstituted beta-ketophosphonates in 55 similar to 70% yields. Furthermore, a convenient one-pot procedure by direct conversion of styrenes to alpha, beta-unsaturated ketones is also developed based on the new catalytic reactions, thus offering a protocol to access two classes of valuable products from simple starting materials.

引用

页码：3290 / 3294

页数：5

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