Obviously Enhanced Fluorescent Signal of Core-Shell Nanostructures through Simultaneous Regulation of Spectral Overlap and Shell Thickness for Imaging and Photothermal Therapy of Ovarian Cancer Cells

被引：1

作者：

Li, Xianyang ^{[1
]}

Huang, Jingyuan ^{[2
]}

Wu, Xin ^{[1
]}

Piao, Xianling ^{[3
]}

Lv, Danning ^{[4
]}

Zhang, Gude ^{[1
]}

Ahn, Dong June ^{[2
]}

Cui, Chunzhi ^{[1
,4
]}

机构：

[1] Yanbian Univ, Dept Chem, Yanji 133002, Peoples R China

[2] Korea Univ, Dept Chem & Biol Engn, Seoul 02841, South Korea

[3] Yanbian Univ, Affiliated Hosp, Yanji 133000, Peoples R China

[4] Yanbian Univ, Coll Integrat Sci, Interdisciplinary Program Biol Funct Mol, Yanji 133002, Jilin, Peoples R China

来源：

PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION | 2023年 / 40卷 / 12期

基金：

新加坡国家研究基金会; 中国国家自然科学基金;

关键词：

gold nanorods; plasmon-enhanced fluorescence; photothermal therapy; PLASMON; POLYDIACETYLENE; NANOPARTICLE; DISTANCE; SILICA; SHAPE;

D O I：

10.1002/ppsc.202300083

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

In this research, by simultaneously regulating the two major factors affecting the plasmonic enhanced fluorescence (PEF), spectral overlap and the distance between the fluororophores and the noble metal nanoparticles, a significantly enhanced fluorescent signal is achieved. Core-shell nanostructures composed of aspect ratio (AR) adjustable gold nanorods (GNRs) and various thickness of SiO2 are prepared and the decorated fluorophores are realized optimized PEF. A typical stimuli-responsive conjugated polymer, polydiacetylene (PDA), and a near-infrared (NIR) dye Cy5.5 are selected as fluorophores and their fluorescent signal are enhanced 7.26 and 4.41 times, respectively. Based on the optimized optical properties, a multifunctional antibody modified Mab-Cy5.5-GNRs@SiO2 is successfully demonstrated the targeting, imaging, and photothermal therapy (PTT) effects on SKOV-3 ovarian cancer cells.

引用

页数：8

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