Towards the total synthesis of aleurodiscal

被引：0
作者：
Zhao, Hai-Xiao
Xu, Jing [1 ]
机构：
[1] Southern Univ Sci & Technol, Shenzhen Grubbs Inst, Shenzhen 518055, Peoples R China
来源：
TETRAHEDRON LETTERS | 2023年 / 125卷
关键词：
Total synthesis; Sesterterpenoids; Aleurodiscal; Cope rearrangement; trans-hydrindane; PALLADIUM-CATALYZED ALLYLATION; TRANSITION-METAL CATALYSIS; ASYMMETRIC TOTAL-SYNTHESIS; CARBON BOND FORMATION; (-)-RETIGERANIC ACID; ASTELLATOL; SESTERTERPENOIDS;
D O I：
10.1016/j.tetlet.2023.154613
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Aleurodiscal is one of the representative members of the isopropyl trans-hydrindane sesterterpenoid family. Herein, we describe our efforts towards the synthesis of a complex sesterterpenoid, aleurodiscal. The key precursor of the Cope rearrangement was concisely synthesized from a known bicyclic starting material in 13 linear steps. Our approach highlighted a Van Leusen homologation reaction and an oxida-tive rearrangement of a tertiary carbinol.& COPY; 2023 Elsevier Ltd. All rights reserved.
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