Low-dose rivaroxaban: can cardiovascular events be reduced?

被引：5

作者：

De Luca, Leonardo ^{[1
,2
]}

机构：

[1] AO San Camillo Forlanini, Dept Cardiothorac & Vasc Med & Surg, Div Cardiol, Circonvallaz Gianicolense 87, I-0052 Rome, Italy

[2] UniCamillus St Camillus Int Univ Hlth Sci, Via St Alessandro 8, I-00131 Rome, Italy

来源：

EUROPEAN HEART JOURNAL SUPPLEMENTS | 2023年 / 25卷

关键词：

Rivaroxaban; Peripheral artery disease; Coronary artery disease; COMPASS trial; PERIPHERAL ARTERY-DISEASE; CHRONIC CORONARY; PLUS ASPIRIN; DOUBLE-BLIND; COMPASS;

D O I：

10.1093/eurheartjsupp/suad034

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Despite available effective guideline-based preventive therapies, patients with vascular diseases remain at high-risk of recurrent ischaemic events. Novel therapeutic strategies are therefore needed in order to further reduce the residual risk that is present in these high-risk patients. The Cardiovascular Outcomes for People using Anticoagulation Strategies trial demonstrated that, in patients with chronic coronary artery disease (CAD) and peripheral artery disease (PAD), a combination of rivaroxaban 2.5 mg/bid (vascular dose) and acetylsalicylic acid (ASA) 100 mg once daily, the so-called dual pathway inhibition (DPI), reduced cardiovascular death, stroke, or myocardial infarction by 24% and mortality by 18%, as compared with ASA-alone. The rationale that can explain the improvement of cardiovascular outcome is that platelet aggregation and fibrin formation are involved in arterial thrombosis and rivaroxaban is able to target both ways and has a synergic effect with ASA. The aim of this review is to discuss the potential mechanisms and added benefits of DPI, in patients with PAD and CAD.

引用

页码：C20 / C26

页数：7

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