Design, Synthesis, Molecular Docking and Antioxidant Evaluation of Benzimidazole-1,3,4 oxadiazole Derivatives

In this research, we synthesised novel benzimidazole-1,3,4 oxadiazole derivatives and studied their antioxidant properties using the DPPH Radical Scavenging Assay. A significant class of substances with a broad range of biological activities is the 1,3,4-benzimidazole family. Furthermore, enabling for various biological activities are the five-membered heterocyclic moieties. Thus, a number of benzimidazole derivatives have been created, there in vitro antioxidant activity has been evaluated, and they have been characterized by FTIR and 1 H NMR spectral studies. Compounds 1A, 2A and 3A have the highest G-score i.e., -7.575 kcal/mol,-6.932 kcal/mol,-6.911 kcal/mol, as compared to standards propyl gallate and Ascorbic acid, which had glide scores of-4.757 kcal/mol and-4.50 kcal/mol respectively. The benzimidazole-1,3,4 oxadiazole containing compounds that were created demonstrated impressive antioxidant activity. When compared to the reference standard, ascorbic acid, (IC50-11.51 +/- 0.31 mu g/ml) Compound 2A demonstrated the strongest antioxidant activity with an IC50 value (53.00 +/- 1.31 mu g/ml) respectively.(c) 2022 Elsevier B.V. All rights reserved.