Phytochemicals as potential target on thioredoxin-interacting protein (TXNIP) for the treatment of cardiovascular diseases

被引:6
作者
Zhou, Peng [1 ]
Ma, Yao-yao [1 ]
Zhao, Xiao-ni [1 ]
Hua, Fang [2 ]
机构
[1] Anhui Univ Chinese Med, Dept Integrated Tradit Chinese & Western Med, Hefei, Anhui, Peoples R China
[2] Anhui Xinhua Univ, Sch Pharm, Hefei, Anhui, Peoples R China
关键词
Cardiovascular disease; TXNIP; Flavonoids; Phenols; Alkaloids; Molecular docking; ISCHEMIA-REPERFUSION INJURY; NF-KAPPA-B; MYOCARDIAL ISCHEMIA/REPERFUSION INJURY; OXIDATIVE STRESS; MITOCHONDRIAL-FUNCTION; ISCHAEMIA/REPERFUSION INJURY; INFLAMMASOME ACTIVATION; ENDOTHELIAL DYSFUNCTION; INDUCED APOPTOSIS; ROSMARINIC ACID;
D O I
10.1007/s10787-022-01130-8
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Cardiovascular diseases (CVDs) are currently the major cause of death and morbidity on a global scale. Thioredoxin-interacting protein (TXNIP) is a marker related to metabolism, oxidation, and inflammation induced in CVDs. The overexpression of TXNIP is closely related to the occurrence and development of CVDs. Hence, TXNIP inhibition is critical for reducing the overactivation of its downstream signaling pathway and, as a result, myocardial cell damage. Due to the chemical variety of dietary phytochemicals, they have garnered increased interest for CVDs prevention and therapy. Phytochemicals are a source of medicinal compounds for a variety of conditions, which aids in the development of effective and safe TXNIP-targeting medications. The objective of this article is to find and virtual screen novel safe, effective, and economically viable TXNIP inhibitors from flavonoids, phenols, and alkaloids derived from foods and plants. The results of the docking study revealed that silibinin, rutin, luteolin, baicalin, procyanidin B2, hesperetin, icariin, and tilianin in flavonoids, polydatin, resveratrol, and salidroside in phenols, and neferine in alkaloids had the highest Vina scores, indicating that these compounds are the active chemicals on TXNIP. In particular, silibinin can be utilized as a lead chemical in the process of structural alteration. These dietary phytochemicals may aid in the discovery of lead compounds for the development of innovative TXNIP agents for the treatment of cardiovascular disease.
引用
收藏
页码:207 / 220
页数:14
相关论文
共 158 条
[1]   Clonal Hematopoiesis-Driver DNMT3A Mutations Alter Immune Cells in Heart Failure [J].
Abplanalp, Wesley Tyler ;
Cremer, Sebastian ;
John, David ;
Hoffmann, Jedrzej ;
Schuhmacher, Bianca ;
Merten, Maximillian ;
Rieger, Michael A. ;
Vasa-Nicotera, Mariuca ;
Zeiher, Andreas M. ;
Dimmeler, Stefanie .
CIRCULATION RESEARCH, 2021, 128 (02) :216-228
[2]   The biological and pharmacological roles of polyphenol flavonoid tilianin [J].
Akanda, Md Rashedunnabi ;
Uddin, Md Nazim ;
Kim, In-Shik ;
Ahn, Dongchoon ;
Tae, Hyun-Jin ;
Park, Byung-Yong .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2019, 842 :291-297
[3]   The protective effect of the cardiac thioredoxin system on the heart in the case of iron overload in mice [J].
Altun, Sevda ;
Budak, Harun .
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY, 2021, 64
[4]   Dimethyl fumarate ameliorates diabetes-associated vascular complications through ROS-TXNIP-NLRP3 inflammasome pathway [J].
Amin, Fatma M. ;
Abdelaziz, Rania R. ;
Hamed, Mohamed F. ;
Nader, Manar A. ;
Shehatou, George S. G. .
LIFE SCIENCES, 2020, 256
[5]   Punicalagin Protects Diabetic Nephropathy by Inhibiting Pyroptosis Based on TXNIP/NLRP3 Pathway [J].
An, Xin ;
Zhang, Yahui ;
Cao, Yuan ;
Chen, Jihua ;
Qin, Hong ;
Yang, Lina .
NUTRIENTS, 2020, 12 (05)
[6]   Silibinin protects H9c2 cardiac cells from oxidative stress and inhibits phenylephrine-induced hypertrophy: potential mechanisms [J].
Anestopoulos, Ioannis ;
Kavo, Anthula ;
Tentes, Ioannis ;
Kortsaris, Alexandros ;
Panayiotidis, Mihalis ;
Lazou, Antigone ;
Pappa, Aglaia .
JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2013, 24 (03) :586-594
[7]   Nano-Soldiers Ameliorate Silibinin Delivery: A Review Study [J].
Ashrafizadeh, Milad ;
Ahmadi, Zahra ;
Mohammadinejad, Reza ;
Farkhondeh, Tahereh ;
Samarghandian, Saeed .
CURRENT DRUG DELIVERY, 2020, 17 (01) :15-22
[8]   Gallic acid: Pharmacological activities and molecular mechanisms involved in inflammation-related diseases [J].
Bai, Jinrong ;
Zhang, Yunsen ;
Tang, Ce ;
Hou, Ya ;
Ai, Xiaopeng ;
Chen, Xiaorui ;
Zhang, Yi ;
Wang, Xiaobo ;
Meng, Xianli .
BIOMEDICINE & PHARMACOTHERAPY, 2021, 133
[9]   The Pharmacological Activity, Biochemical Properties, and Pharmacokinetics of the Major Natural Polyphenolic Flavonoid: Quercetin [J].
Batiha, Gaber El-Saber ;
Beshbishy, Amany Magdy ;
Ikram, Muhammad ;
Mulla, Zohair S. ;
Abd El-Hack, Mohamed E. ;
Taha, Ayman E. ;
Algammal, Abdelazeem M. ;
Elewa, Yaser Hosny Ali .
FOODS, 2020, 9 (03)
[10]   Apigenin Attenuates β-Receptor-Stimulated Myocardial Injury Via Safeguarding Cardiac Functions and Escalation of Antioxidant Defence System [J].
Buwa, Chhabildas C. ;
Mahajan, Umesh B. ;
Patil, Chandragouda R. ;
Goyal, Sameer N. .
CARDIOVASCULAR TOXICOLOGY, 2016, 16 (03) :286-297