The application of JAK inhibitors in the peri-transplantation period of hematopoietic stem cell transplantation for myelofibrosis

被引：1

作者：

Wang, Zerong ^{[1
]}

Jin, Xuelian ^{[1
]}

Zeng, Jiajia ^{[1
]}

Xiong, Zilin ^{[1
]}

Chen, Xinchuan ^{[1
]}

机构：

[1] Sichuan Univ, West China Hosp, Chengdu, Sichuan, Peoples R China

来源：

ANNALS OF HEMATOLOGY | 2024年 / 103卷 / 09期

关键词：

Myelofibrosis; JAK inhibitors; Ruxolitinib; Allogeneic hematopoietic stem cell transplantation; Poor implantation; Graft-versus-host disease; GANDOTINIB LY2784544; COMFORT-II; RUXOLITINIB; OUTCOMES; SAFETY; DISEASE; PACRITINIB; FEDRATINIB; EFFICACY; THERAPY;

D O I：

10.1007/s00277-024-05703-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Myelofibrosis (MF) is a myeloproliferative neoplasm (MPN) with a poor prognosis, and allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the only treatment with curative potential. Ruxolitinib, a JAK1/2 inhibitor, has shown promising results in improving patients' symptoms, overall survival, and quality of life, and can be used as a bridging therapy to HSCT that increases the proportion of transplantable patients. However, the effect of this and similar drugs on HSCT outcomes is unknown, and the reports on their efficacy and safety in the peri-transplantation period vary widely in the published literature. This paper reviews clinical data related to the use of JAK inhibitors in the peri-implantation phase of hematopoietic stem cell transplantation for primary myelofibrosis and discusses their efficacy and safety.

引用

页码：3293 / 3301

页数：9

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