The Role of the Gut Microbiome and Microbial Dysbiosis in Common Skin Diseases

被引:19
作者
Rygula, Izabella [1 ]
Pikiewicz, Wojciech [2 ]
Grabarek, Beniamin Oskar [2 ]
Wojcik, Michal [2 ]
Kaminiow, Konrad [2 ]
机构
[1] Med Univ Silesia, Fac Med Sci Katowice, PL-40752 Katowice, Poland
[2] WSB Univ, Collegium Medicum, Fac Med, PL-41300 Dabrowa Gornicza, Poland
关键词
microbiome; gut; dermatologic conditions; acne; psoriasis; alopecia areata; atopic dermatitis; dermatology; skin; CHAIN FATTY-ACIDS; QUALITY-OF-LIFE; ATOPIC-DERMATITIS; AKKERMANSIA-MUCINIPHILA; GASTROINTESTINAL-TRACT; ACNE-VULGARIS; PSORIASIS; INFANTS; MODERATE; PATHOGENESIS;
D O I
10.3390/ijms25041984
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Dermatoses are an increasingly common problem, particularly in developed countries. The causes of this phenomenon include genetic factors and environmental elements. More and more scientific reports suggest that the gut microbiome, more specifically its dysbiosis, also plays an important role in the induction and progression of diseases, including dermatological diseases. The gut microbiome is recognised as the largest endocrine organ, and has a key function in maintaining human homeostasis. In this review, the authors will take a close look at the link between the gut-skin axis and the pathogenesis of dermatoses such as atopic dermatitis, psoriasis, alopecia areata, and acne. The authors will also focus on the role of probiotics in remodelling the microbiome and the alleviation of dermatoses.
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页数:22
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