The Functions of N6-Methyladenosine in Nuclear RNAs

被引：2
作者：
Zhigalova, Nadezhda A. [1 ]
Oleynikova, Katerina Yu. [1 ]
Ruzov, Alexey S. [1 ]
Ermakov, Alexander S. [1 ,2 ]
机构：
[1] Russian Acad Sci, Inst Bioengn, Res Ctr Biotechnol, Moscow 119071, Russia
[2] Lomonosov Moscow State Univ, Fac Biol, Moscow 119991, Russia
来源：
BIOCHEMISTRY-MOSCOW | 2024年 / 89卷 / 01期
基金：
俄罗斯科学基金会;
关键词：
RNA modifications; N-6-methyladenosine (m(6)A); methyltransferases METTL3 and METTL14; demethylases FTO and ALKBH5; m(6)A-binding proteins of the YTHDF and YTHDC families; chromatin; R-loops; R-LOOP FORMATION; MESSENGER-RNA; GENE-EXPRESSION; METHYLATION; CHROMATIN; TRANSCRIPTION; N6-METHYLADENOSINE; PROTEINS; RESIDUES; REVEALS;
D O I：
10.1134/S0006297924010103
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
N-6-methyladenosine (m(6)A) is one of the most common modifications in both eukaryotic and prokaryotic mRNAs. It has been experimentally confirmed that m(6)A methylation is involved in the regulation of stability and translation of various mRNAs. Until recently, the majority of m(6)A-related studies have been focused on the cytoplasmic functions of this modification. Here, we review new data on the role of m(6)A in several key biological processes taking place in the cell nucleus, such as transcription, chromatin organization, splicing, nuclear-cytoplasmic transport, and R-loop metabolism. Based on analysis of these data, we suggest that m(6)A methylation of nuclear RNAs is another level of gene expression regulation which, together with DNA methylation and histone modifications, controls chromatin structure and functioning in various biological contexts.
引用
收藏
页码：159 / 172
页数：14
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