Rationally designed block copolymer- based nanoarchitectures: An emerging paradigm for effective drug delivery

被引：3

作者：

Sharma, Rajeev ^{[1
]}

Shrivastava, Priya ^{[2
]}

Gautam, Laxmikant ^{[2
,3
]}

Agrawal, Udita ^{[2
]}

Lakshmi, S. Mohana ^{[1
]}

Vyas, Suresh P. ^{[2
]}

机构：

[1] Amity Univ Madhya Pradesh, Amity Inst Pharm, Gwalior 474005, MP, India

[2] Dr Harisingh Gour Cent Univ, Dept Pharmaceut Sci, Drug Delivery Res Lab, Sagar 470003, MP, India

[3] Babulal Tarabai Inst Pharmaceut Sci, Sagar 470228, MP, India

来源：

DRUG DISCOVERY TODAY | 2023年 / 28卷 / 11期

关键词：

block copolymer; nanomedicines; drug delivery; bioactives; RADICAL POLYMERIZATION; RECENT PROGRESS; NANOPARTICLES; MICELLES; NANOMEDICINE; NANOSPHERES; COMPOSITES; HYDROGELS; SYSTEMS;

D O I：

10.1016/j.drudis.2023.103786

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Various polymeric materials have been investigated to produce unique modes of delivery for drug modules to achieve either temporal or spatial control of bioactives delivery. However, after intravenous administration, phagocytic cells quickly remove these nanostructures from the systemic circulation via the reticuloendothelial system (RES). To overcome these concerns, ecofriendly block copolymers are increasingly being investigated as innovative carriers for the delivery of bioactives. In this review, we discuss the design, fabrication techniques, and recent advances in the development of block copolymers and their applications as drug carrier systems to improve the physicochemical and pharmacological attributes of bioactives.

引用

页数：16

共 112 条

[1]

Abuwatfa WH., 2022, Polymeric Micelles for Drug Delivery, P531, DOI [10.1016/B978-0-323-89868-3.00023-9, DOI 10.1016/B978-0-323-89868-3.00023-9]

[2] Amphiphilic block copolymers for drug delivery [J].

Adams, ML ;

Lavasanifar, A ;

Kwon, GS .

JOURNAL OF PHARMACEUTICAL SCIENCES, 2003, 92 (07) :1343-1355

[3] Advances and applications of block-copolymer-based nanoformulations [J].

Agrahari, Vibhuti ;

Agrahari, Vivek .

DRUG DISCOVERY TODAY, 2018, 23 (05) :1139-1151

[4] Composite Nanoformulation Therapeutics for Long-Term Ocular Delivery of Macromolecules [J].

Agrahari, Vibhuti ;

Agrahari, Vivek ;

Hung, Wei-Ting ;

Christenson, Lane K. ;

Mitra, Ashim K. .

MOLECULAR PHARMACEUTICS, 2016, 13 (09) :2912-2922

[5] Nanocarrier fabrication and macromolecule drug delivery: challenges and opportunities [J].

Agrahari, Vibhuti ;

Agrahari, Vivek ;

Mitra, Ashim K. .

THERAPEUTIC DELIVERY, 2016, 7 (04) :257-278

[6] High Molecular Weight Block Copolymers by Sequential Monomer Addition via Cu(0)-Mediated Living Radical Polymerization (SET-LRP): An Optimized Approach [J].

Anastasaki, Athina ;

Waldron, Christopher ;

Wilson, Paul ;

Boyer, Cyrille ;

Zetterlund, Per B. ;

Whittaker, Michael R. ;

Haddleton, David .

ACS MACRO LETTERS, 2013, 2 (10) :896-900

[7] Biodegradable polycaprolactone (PCL) based polymer and composites [J].

Archer, Emily ;

Torretti, Marissa ;

Madbouly, Samy .

PHYSICAL SCIENCES REVIEWS, 2021, :4391-4414

[8] Synthesis and Self-Assembly of ABn Miktoarm Star Polymers [J].

Bates, Morgan W. ;

Barbon, Stephanie M. ;

Levi, Adam E. ;

Lewis, Ronald M., III ;

Beech, Haley K. ;

Vonk, Kasper M. ;

Zhang, Cheng ;

Fredrickson, Glenn H. ;

Hawker, Craig J. ;

Bates, Christopher M. .

ACS MACRO LETTERS, 2020, 9 (03) :396-403

[9] Biodegradable PEG-PCL Nanoparticles for Co-delivery of MUC1 Inhibitor and Doxorubicin for the Confinement of Triple-Negative Breast Cancer [J].

Behl, Akanksha ;

Solanki, Subhash ;

Paswan, Shravan K. ;

Datta, Tirtha K. ;

Saini, Adesh K. ;

Saini, Reena, V ;

Parmar, Virinder S. ;

Thakur, Vijay Kumar ;

Malhotra, Shashwat ;

Chhillar, Anil K. .

JOURNAL OF POLYMERS AND THE ENVIRONMENT, 2023, 31 (03) :999-1018

[10] Block Copolymer Micelles in Nanomedicine Applications [J].

Cabral, Horacio ;

Miyata, Kanjiro ;

Osada, Kensuke ;

Kataoka, Kazunori .

CHEMICAL REVIEWS, 2018, 118 (14) :6844-6892

← 1 2 3 4 5 6 7 8 9 10 →