Delayed melatonin circadian timing, lower melatonin output, and sleep disruptions in myopic, or short-sighted, children

被引:11
作者
Chakraborty, Ranjay [1 ,5 ]
Seby, Chris [1 ]
Scott, Hannah [2 ]
Tang, Victoria [1 ]
Kemps, Eva [3 ]
Anstice, Nicola [1 ]
Juers, Emilia [1 ]
Lovato, Nicole [2 ]
Taranath, Deepa A. [4 ]
Mills, Richard A. [4 ]
Lack, Leon C. [2 ,3 ]
机构
[1] Flinders Univ S Australia, Caring Futures Inst, Coll Nursing & Hlth Sci, Myopia & Visual Dev Lab, Adelaide, SA, Australia
[2] Flinders Univ S Australia, Flinders Hlth & Med Res Inst Sleep Hlth, Adelaide, SA, Australia
[3] Flinders Univ S Australia, Coll Educ Psychol & Social Work, Adelaide, SA, Australia
[4] Flinders Univ S Australia, Flinders Hlth & Med Res Inst, Dept Ophthalmol, Adelaide, SA, Australia
[5] Flinders Univ S Australia, Coll Nursing & Hlth Sci, Sturt North, Adelaide, SA, Australia
关键词
melatonin; circadian rhythms; myopia; sleep; dim-light melatonin onset; urinary; 6-sulphatoxymelatonin; cognition; refractive error; axial eye length; COGNITIVE DYSFUNCTION; CHOROIDAL THICKNESS; SALIVARY MELATONIN; DIURNAL RHYTHMS; PLASMA; LIGHT; HUMANS; AGE; REPEATABILITY; ACTIGRAPHY;
D O I
10.1093/sleep/zsad265
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Study Objectives: This study investigated the differences in melatonin circadian timing and output, sleep characteristics, and cognitive function in myopic and non-myopic (or emmetropic) children, aged 8-15 years.Methods: Twenty-six myopes (refractive error [mean +/- standard error mean] -2.06 +/- 0.23 diopters) and 19 emmetropes (-0.06 +/- 0.04 diopters), aged 11.74 +/- 2.31 years were recruited. Circadian timing was assessed using salivary dim-light melatonin onset (DLMO), collected half-hourly for 7 hours, beginning 5 hours before and finishing 2 hours after individual average sleep onset in a sleep laboratory. Nocturnal melatonin output was assessed via aMT6s levels from urine voids collected from 05:30 pm to 8:00 am the following morning. Actigraphy-derived objective sleep timing were acquired for a week prior to the sleep laboratory visit. Cognitive assessments of sustained attention (using psychomotor vigilance task [PVT]) and working memory (using digit spans) were performed on the night of sleep laboratory.Results: Myopic children (9:07 pm +/- 14 minutes) exhibited a DLMO phase-delay of 1 hour 8 minutes compared to emmetropes (7:59 pm +/- 13 minutes), p = 0.002. aMT6s melatonin levels were significantly lower among myopes (18.70 +/- 2.38) than emmetropes (32.35 +/- 6.93, p = 0.001). Myopes also exhibited significantly delayed sleep onset, delayed wake-up time, poor and reduced sleep, and more evening-type diurnal preference than emmetropes (all p < 0.05). Finally, myopes showed a slower reaction time in the PVT (p < 0.05), but not digit span tasks at night.Conclusions: These findings suggest a potential association between circadian rhythm dysfunction and myopia in children.
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页数:16
相关论文
共 89 条
[1]   The ipRGC-Driven Pupil Response with Light Exposure, Refractive Error, and Sleep [J].
Abbott, Kaleb S. ;
Queener, Hope M. ;
Ostrin, Lisa A. .
OPTOMETRY AND VISION SCIENCE, 2018, 95 (04) :323-331
[2]   The role of actigraphy in the study of sleep and circadian rhythms [J].
Ancoli-Israel, S ;
Cole, R ;
Alessi, C ;
Chambers, M ;
Moorcroft, W ;
Pollak, CP .
SLEEP, 2003, 26 (03) :342-392
[3]   Do Evidence-Based Treatments for Circadian Rhythm Sleep-Wake Disorders Make the GRADE? Updated Guidelines Point to Need for More Clinical Research [J].
Auger, R. Robert ;
Burgess, Helen J. ;
Emens, Jonathan S. ;
Deriy, Ludmila V. ;
Sharkey, Katherine M. .
JOURNAL OF CLINICAL SLEEP MEDICINE, 2015, 11 (10) :1079-1080
[4]   Decreased sleep quality in high myopia children [J].
Ayaki, Masahiko ;
Torii, Hidemasa ;
Tsubota, Kazuo ;
Negishi, Kazuno .
SCIENTIFIC REPORTS, 2016, 6
[5]   Cognitive, Behavioral, and Functional Consequences of Inadequate Sleep in Children and Adolescents [J].
Beebe, Dean W. .
PEDIATRIC CLINICS OF NORTH AMERICA, 2011, 58 (03) :649-+
[6]  
Brainard GC, 2001, J NEUROSCI, V21, P6405
[7]  
Braun C I, 1996, Ophthalmic Epidemiol, V3, P13, DOI 10.3109/09286589609071597
[8]  
Buckhalt Joseph A, 2011, WMF Press Bull, V2011, P1
[9]   Myopia Control: Why Each Diopter Matters [J].
Bullimore, Mark A. ;
Brennan, Noel A. .
OPTOMETRY AND VISION SCIENCE, 2019, 96 (06) :463-465
[10]   Ocular and Systemic Diurnal Rhythms in Emmetropic and Myopic Adults [J].
Burfield, Hannah J. ;
Carkeet, Andrew ;
Ostrin, Lisa A. .
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2019, 60 (06) :2237-2247