Glucose-6-phosphate dehydrogenase deficiency and long-term risk of immune-related disorders

被引:4
作者
Israel, Ariel [1 ,2 ,3 ]
Schaffer, Alejandro A. [4 ]
Berkovitch, Matitiahu [2 ,3 ,5 ]
Ozeri, David J. [1 ,6 ]
Merzon, Eugene [1 ,7 ]
Green, Ilan [1 ,2 ,3 ]
Golan-Cohen, Avivit [1 ,2 ,3 ]
Ruppin, Eytan [4 ]
Vinker, Shlomo [1 ,2 ,3 ]
Magen, Eli [1 ,8 ]
机构
[1] Leumit Hlth Serv, Leumit Res Inst, Tel Aviv, Israel
[2] Tel Aviv Univ, Fac Med, Sch Publ Hlth, Tel Aviv, Israel
[3] Tel Aviv Univ, Fac Med, Family Med Dept, Tel Aviv, Israel
[4] NCI, Canc Data Sci Lab, Bethesda, MD USA
[5] Shamir Med Ctr, Clin Pharmacol & Toxicol Unit, Zerifin, Israel
[6] Sheba Med Ctr, Div Rheumatol, Ramat Gan, Israel
[7] Ariel Univ, Adelson Sch Med, Ariel, Israel
[8] Bengur Univ, Assuta Ashdod Univ Hosp, Fac Hlth Sci, Med Dept, Beer Sheva, Israel
来源
FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷
基金
美国国家卫生研究院;
关键词
G6PD deficiency; autoimmunity; allergy; infectious diseases; fibromyalgia; hidradenitis suppurativa; rheumatoid arthritis; lupus (SLE); G6PD DEFICIENCY; DISEASE; ORIGIN; PTPN22; CELLS; LEADS;
D O I
10.3389/fimmu.2023.1232560
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Introduction: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X linked enzymatic disorder that is particularly prevalent in Africa, Asia, and the Middle East. This study aimed to assess the long-term health risks associated with G6PD deficiency. Methods: A retrospective cohort study was conducted using data from a national healthcare provider in Israel (Leumit Health Services). A total of 7,473 G6PD-deficient individuals were matched with 29,892 control subjects in a 1:4 ratio, based on age, gender, socioeconomic status, and ethnic groups. The exposure of interest was recorded G6PD diagnosis or positive G6PD diagnostic test. The main outcomes and measures included rates of infectious diseases, allergic conditions, and autoimmune disorders between 2002 and 2022. Results: Significantly increased rates were observed for autoimmune disorders, infectious diseases, and allergic conditions in G6PD-deficient individuals compared to the control group. Specifically, notable increases were observed for rheumatoid arthritis (odds ratio [OR] 2.41, p<0.001), systemic lupus erythematosus (OR 4.56, p<0.001), scleroderma (OR 6.87, p<0.001), pernicious anemia (OR 18.70, p<0.001), fibromyalgia (OR 1.98, p<0.001), Graves' disease (OR 1.46, p=0.001), and Hashimoto's thyroiditis (OR 1.26, p=0.001). These findings were supported by elevated rates of positive autoimmune serology and higher utilization of medications commonly used to treat autoimmune conditions in the G6PD-deficient group. Discussion: In conclusion, individuals with G6PD deficiency are at a higher risk of developing autoimmune disorders, infectious diseases, and allergic conditions. This large-scale observational study provides valuable insights into the comprehensive association between G6PD deficiency and infectious and immune-related diseases. The findings emphasize the importance of considering G6PD deficiency as a potential risk factor in clinical practice and further research is warranted to better understand the underlying mechanisms of these associations.
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页数:11
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