A Case of Corticobasal Syndrome and Posterior Cortical Atrophy With Biomarkers of Alzheimer Disease

被引：1

作者：

Sugimura, Yoko ^{[1
,2
]}

Baba, Toru ^{[1
]}

Ezura, Michinori ^{[3
]}

Kikuchi, Akio ^{[3
,4
]}

Hasegawa, Takafumi ^{[3
]}

Nagano, Isao ^{[5
]}

Suzuki, Kyoko ^{[6
]}

Takeda, Atsushi ^{[1
,2
,7
]}

机构：

[1] Tohoku Univ, Natl Hosp Org Sendai Nishitaga Hosp, Grad Sch Med, Dept Neurol, Sendai, Japan

[2] Tohoku Univ, Grad Sch Med, Dept Cognit & Motor Aging, Sendai, Japan

[3] Tohoku Univ, Grad Sch Med, Dept Neurol, Sendai, Japan

[4] Yamagata Prefectural Univ Hlth Sci, Dept Occupat Therapy, Yamagata, Japan

[5] Natl Hosp Org, Miyagi Hosp, Dept Neurol, Watarai, Miyagi, Japan

[6] Tohoku Univ, Grad Sch Med, Dept Behav Neurol & Cognit Neurosci, Sendai, Japan

[7] Natl Hosp Org, Sendai Nishitaga Hosp, Dept Neurol, 2-11-11,Kagitorihoncho,Taihaku Ku, Sendai, Miyagi, Japan

来源：

ALZHEIMER DISEASE & ASSOCIATED DISORDERS | 2023年 / 37卷 / 03期

关键词：

CBS; AD; PCA; biomarker; DIAGNOSIS;

D O I：

10.1097/WAD.0000000000000560

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Corticobasal syndrome is a clinical entity characterized by asymmetric akinetic rigidity and a variety of higher cortical dysfunction. Predicting background pathology of corticobasal syndrome is rather challenging; however, clinical and neuroimaging findings may provide a clue to its etiopathological origin. Visuospatial dysfunction of posterior cortical atrophy and logopenic-type language impairment indicate the presence of Alzheimer's disease-related pathology, and they provide useful information in distinguishing Alzheimer's disease from other types of corticobasal syndrome. Here we describe a case of corticobasal syndrome who showed characteristic visuospatial symptoms with imaging evidence of Alzheimer's disease supported by amyloid-PET and tau/astrogliosis-PET. Early, accurate diagnosis based on clinical features and predictable biomarkers is mandatory to the success of early intervention in corticobasal syndrome associated with Alzheimer's disease.

引用

页码：243 / 245

页数：3

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