Serum ferritin values in neonates <29 weeks' gestation are highly variable and do not correlate with reticulocyte hemoglobin content

被引：6

作者：

Bahr, Timothy J. ^{[1
,2
]}

Tan, Sylvia ^{[3
]}

Smith, Emily

Beauman, Sandra S. ^{[4
]}

Schibler, Kurt R. ^{[5
]}

Grisby, Cathy A. ^{[5
]}

Lowe, Jean R. ^{[4
]}

Bell, Edward F. ^{[6
]}

Laptook, Abbot R. ^{[7
]}

Shankaran, Seetha ^{[8
]}

Carlton, David P. ^{[9
]}

Rau, Carrie ^{[1
]}

Baserga, Mariana C. ^{[1
]}

Flibotte, John ^{[10
]}

Zaterka-Baxter, Kristin ^{[3
]}

Walsh, Michele C. ^{[11
]}

Das, Abhik

Christensen, Robert D. ^{[2
]}

Ohls, Robin K.

机构：

[1] Univ Utah Hlth, Dept Pediat, Div Neonatol, Salt Lake City, UT 84112 USA

[2] Intermt Healthcare, Dept Neonatol, Murray, UT 84107 USA

[3] RTI Int, Social Stat & Environm Sci Unit, Washington, DC USA

[4] Univ New Mexico, Dept Pediat, Albuquerque, NM USA

[5] Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH USA

[6] Univ Iowa, Dept Pediat, Iowa City, IA USA

[7] Brown Univ, Dept Pediat, Providence, RI USA

[8] Wayne State Univ, Dept Pediat, Detroit, MI USA

[9] Emory Univ, Dept Pediat, Atlanta, GA USA

[10] Univ Penn, Dept Pediat, Philadelphia, PA USA

[11] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Div Extramural Res, Bethesda, MD USA

来源：

JOURNAL OF PERINATOLOGY | 2023年 / 43卷 / 11期

关键词：

COULTER DXH 800; IRON-DEFICIENCY; REFERENCE INTERVALS; TERM INFANTS; BIRTH; EQUIVALENT; SAPPHIRE; CHILDREN; PRETERM; MARKER;

D O I：

10.1038/s41372-023-01751-z

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

ObjectivesTo compare serum ferritin and RET-He values among extremely low gestational age neonates ELGANs with other markers of iron-deficient erythropoiesis.Study DesignThis is a secondary analysis of the NICHD Darbepoetin Trial. Study data from placebo recipients who had a serum ferritin, a RET-He, and a mean corpuscular volume (MCV) measurement within a 24-hour period were analyzed for correlation.ResultsMixed linear regression models showed no association between ferritin and RET-He at both early (& beta; = 0.0016, p = 0.40) and late (& beta; = -0.0001, p = 0.96) time points. Positive associations were observed between RET-He and MCV at baseline, early, and late time points (p < 0.01, =0.01, <0.001, respectively), while ferritin was not associated with MCV at any time point.ConclusionsOur study shows that RET-He is better correlated with MCV as a marker of iron-limited erythropoiesis than ferritin. The results suggest that ferritin is limited as a marker of iron sufficiency in premature infants.Study IdentificationFDA IND Number 100138; ClinicalTrials.gov number NCT03169881; NRN ID number NICHD-NRN-0058 (Darbe).

引用

页码：1368 / 1373

页数：6

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