Cafeteria Diet-Induced Obesity Worsens Experimental CKD

被引：0
|
作者：
Laget, Jonas [1 ]
Cortijo, Irene [1 ]
Boukhaled, Juliana H. H. [1 ]
Muyor, Karen [1 ]
Duranton, Flore [1 ]
Jover, Bernard [1 ]
Raynaud, Fabrice [2 ]
Lajoix, Anne-Dominique [3 ]
Argiles, Angel [1 ]
Gayrard, Nathalie [1 ]
机构：
[1] RD Nephrol, F-34090 Montpellier, France
[2] Univ Montpellier, PhyMedExp, INSERM, CNRS, F-34090 Montpellier, France
[3] Univ Montpellier, Biocommun Cardiometab BC2M, F-34090 Montpellier, France
来源：
NUTRIENTS | 2023年 / 15卷 / 15期
基金：
欧盟地平线“2020”;
关键词：
chronic kidney disease; obesity; adipokine; fibrosis; collagen; macrophage; inflammation; CHRONIC KIDNEY-DISEASE; DIPEPTIDYL PEPTIDASE-4; INSULIN-RESISTANCE; METABOLIC SYNDROME; ADIPOSE; INFLAMMATION; GLOMERULOPATHY; FIBROSIS; LEPTIN; MODEL;
D O I：
10.3390/nu15153331
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Obesity is a significant risk factor for chronic kidney disease (CKD). This study aimed to evaluate the impact of obesity on the development of kidney fibrosis in a model of cafeteria diet rats undergoing 5/6th nephrectomy (SNx). Collagen 1, 3, and 4 expression, adipocyte size, macrophage number, and the expression of 30 adipokines were determined. Collagen 1 expression in kidney tissue was increased in Standard-SNx and Cafeteria-SNx (7.1 & PLUSMN; 0.6% and 8.9 & PLUSMN; 0.9 tissue area, respectively). Renal expression of collagen 3 and 4 was significantly increased (p < 0.05) in Cafeteria-SNx (8.6 & PLUSMN; 1.5 and 10.9 & PLUSMN; 1.9% tissue area, respectively) compared to Cafeteria (5.2 & PLUSMN; 0.5 and 6.3 & PLUSMN; 0.6% tissue area, respectively). Adipocyte size in eWAT was significantly increased by the cafeteria diet. In Cafeteria-SNx, we observed a significant increase in macrophage number in the kidney (p = 0.01) and a consistent tendency in eWAT. The adipokine level was higher in the Cafeteria groups. Interleukin 11, dipeptidyl peptidase 4, and serpin 1 were increased in Cafeteria-SNx. In the kidney, collagen 3 and 4 expressions and the number of macrophages were increased in Cafeteria-SNx, suggesting an exacerbation by preexisting obesity of CKD-induced renal inflammation and fibrosis. IL11, DPP4, and serpin 1 can act directly on fibrosis and participate in the observed worsening CKD.
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页数：13
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