Association between Diethylhexyl Phthalate Exposure with Folliculogenesis and Ovarian Steroidogenesis: A Systematic Review and Meta-Analysis

被引：0
作者：
Hu, Weihuan [1 ]
Wu, Yan [1 ]
Zhu, Yuhang [1 ]
Wang, Fangfang [1 ]
Qu, Fan [1 ]
机构：
[1] Zhejiang Univ, Womens Hosp, Sch Med, Dept Chinese Integrat Med, Hangzhou 310006, Zhejiang, Peoples R China
来源：
CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY | 2023年 / 50卷 / 07期
关键词：
systematic review; diethylhexyl phthalate (DEHP); mono(2-ethylhexyl) phthalate (MEHP); folliculogenesis; ovarian steroidogenesis; estradiol; progesterone; meta-analysis; DI(2-ETHYLHEXYL) PHTHALATE; DI-(2-ETHYLHEXYL) PHTHALATE; PRENATAL EXPOSURE; IN-UTERO; COLLABORATIVE WORK; DEHP; FERTILITY; TOXICITY; ONSET; CELL;
D O I：
10.31083/j.ceog5007150
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Background: Environmental endocrine disruptor-diethylhexyl phthalate (DEHP) or its active metabolites-mono(2-ethylhexyl) phthalate (MEHP) has the greatest endocrine disrupting potency. The present systematic review and meta-analysis was to investigate the effects of DEHP/MEHP exposure on the folliculogenesis and ovarian steroidogenesis in female rodents. Methods: A search was conducted using EMBASE, PubMed, Web of Science, and Cochrance Library databases. The meta-analyses were performed using mean difference (MD) and random-effects model. Risk of bias and subgroup analyses were assessed using Revman 5.4.1 and R 4.1.2. Registration number: PROSPERO CRD42021292264. Results: A total of 15 studies were included in this systematic review. We found that the exposure of DEHP/MEHP significantly increased the ovary weight (p = 0.003), decreased the serum progesterone levels (p = 0.0008) and delayed the vaginal opening (p = 0.01). Conclusions: The DEHP/MEHP exposure has adverse effects on some aspects of female reproduction ability which tested in female rodent. However, more evidence is needed to strengthen the conclusion.
引用
收藏
页数：12
相关论文
共 48 条
[41]  
U.S.EPA, 1987, Di(2-ethylhexyl)phthalate (DEHP)
[42]   Exposure to pollutants altered glucocorticoid signaling and clock gene expression in female mice. Evidence of tissue- and sex-specificity [J].
Vega, Nathalie ;
Pinteur, Claudie ;
Buffelan, Gael ;
Loizon, Emmanuelle ;
Vidal, Hubert ;
Naville, Danielle ;
Le Magueresse-Battistoni, Brigitte .
CHEMOSPHERE, 2021, 262 (262)
[43]   Systematic review and meta-analysis of early life exposure to di(2-ethylhexyl) phthalate and obesity related outcomes in rodents [J].
Wassenaar, Pim Nicolaas Hubertus ;
Legler, Juliette .
CHEMOSPHERE, 2017, 188 :174-181
[44]  
World Health Orgnization (WHO), 2022, WHOPCSEDC022
[45]   Opposite effects of high- and low-dose di-(2-ethylhexyl) phthalate (DEHP) exposure on puberty onset, oestrous cycle regularity and hypothalamic kisspeptin expression in female rats [J].
Yu Zhen ;
Wang Fan ;
Han Junyong ;
Lu Rongmei ;
Li Qian ;
Cai Liangchun ;
Li Bishuang ;
Chen Jinyan ;
Wang Kun ;
Lin Wenjin ;
Lin Qinghua ;
Chen Gang ;
Wen Junping .
REPRODUCTION FERTILITY AND DEVELOPMENT, 2020, 32 (06) :610-618
[46]   Effect of Parecoxib on Postoperative Pain Management After Total Knee/Hip Arthroplasty: A Systematic Review and Meta-Analysis [J].
Zallipalli, Sri Nikhil ;
Bethi, Rakesh Reddy ;
Kandru, Madhuri ;
Dendukuri, Nikith Kashyap ;
Gandla, Geethanjali ;
Vemuri, Sree Sai Siddhardha ;
Peri, Harish ;
Linga, Saichand .
CUREUS JOURNAL OF MEDICAL SCIENCE, 2022, 14 (12)
[47]   The role of exposure to phthalates in variations of anogenital distance: A systematic review and meta-analysis [J].
Zarean, Maryam ;
Keikha, Mojtaba ;
Feizi, Awat ;
Kazemitabaee, Maryamsadat ;
Kelishadi, Roya .
ENVIRONMENTAL POLLUTION, 2019, 247 :172-179
[48]   Effects of an Environmentally Relevant Phthalate Mixture on Cultured Mouse Antral Follicles [J].
Zhou, Changqing ;
Flaws, Jodi A. .
TOXICOLOGICAL SCIENCES, 2017, 156 (01) :217-229
12345