Association between Diethylhexyl Phthalate Exposure with Folliculogenesis and Ovarian Steroidogenesis: A Systematic Review and Meta-Analysis

被引：0
作者：
Hu, Weihuan [1 ]
Wu, Yan [1 ]
Zhu, Yuhang [1 ]
Wang, Fangfang [1 ]
Qu, Fan [1 ]
机构：
[1] Zhejiang Univ, Womens Hosp, Sch Med, Dept Chinese Integrat Med, Hangzhou 310006, Zhejiang, Peoples R China
来源：
CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY | 2023年 / 50卷 / 07期
关键词：
systematic review; diethylhexyl phthalate (DEHP); mono(2-ethylhexyl) phthalate (MEHP); folliculogenesis; ovarian steroidogenesis; estradiol; progesterone; meta-analysis; DI(2-ETHYLHEXYL) PHTHALATE; DI-(2-ETHYLHEXYL) PHTHALATE; PRENATAL EXPOSURE; IN-UTERO; COLLABORATIVE WORK; DEHP; FERTILITY; TOXICITY; ONSET; CELL;
D O I：
10.31083/j.ceog5007150
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Background: Environmental endocrine disruptor-diethylhexyl phthalate (DEHP) or its active metabolites-mono(2-ethylhexyl) phthalate (MEHP) has the greatest endocrine disrupting potency. The present systematic review and meta-analysis was to investigate the effects of DEHP/MEHP exposure on the folliculogenesis and ovarian steroidogenesis in female rodents. Methods: A search was conducted using EMBASE, PubMed, Web of Science, and Cochrance Library databases. The meta-analyses were performed using mean difference (MD) and random-effects model. Risk of bias and subgroup analyses were assessed using Revman 5.4.1 and R 4.1.2. Registration number: PROSPERO CRD42021292264. Results: A total of 15 studies were included in this systematic review. We found that the exposure of DEHP/MEHP significantly increased the ovary weight (p = 0.003), decreased the serum progesterone levels (p = 0.0008) and delayed the vaginal opening (p = 0.01). Conclusions: The DEHP/MEHP exposure has adverse effects on some aspects of female reproduction ability which tested in female rodent. However, more evidence is needed to strengthen the conclusion.
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页数：12
相关论文
共 48 条
[1]   Assessing the concentration of phthalate esters (PAEs) and bisphenol A (BPA) and the genotoxic potential of treated wastewater (final effluent) in Saudi Arabia [J].
Al-Saleh, Iman ;
Elkhatib, Rola ;
Al-Rajoudi, Tahreer ;
Al-Qudaihi, Ghofran .
SCIENCE OF THE TOTAL ENVIRONMENT, 2017, 578 :440-451
[2]   Editorial: Polycystic ovary resistance, and molecular syndrome, insulin defects of insulin signaling [J].
Azziz, R .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2002, 87 (09) :4085-4087
[3]   Assessing human exposure to phthalates using monoesters and their oxidized metabolites as biomarkers [J].
Barr, DB ;
Silva, MJ ;
Kato, K ;
Reidy, JA ;
Malek, NA ;
Hurtz, D ;
Sadowski, M ;
Needham, LL ;
Calafat, AM .
ENVIRONMENTAL HEALTH PERSPECTIVES, 2003, 111 (09) :1148-1151
[4]   ALTERED STEROIDOGENESIS IN WHOLE-OVARY AND ADRENAL CULTURE IN CYCLING RATS [J].
BERMAN, E ;
LASKEY, JW .
REPRODUCTIVE TOXICOLOGY, 1993, 7 (04) :349-358
[5]   Prenatal Exposure to Di(2-Ethylhexyl) Phthalate Causes Long-Term Transgenerational Effects on Female Reproduction in Mice [J].
Brehm, Emily ;
Rattan, Saniya ;
Gao, Liying ;
Flaws, Jodi A. .
ENDOCRINOLOGY, 2018, 159 (02) :795-809
[6]  
de Vries RBM., 2015, Evid. -Based Preclin. Med., V2, P1, DOI DOI 10.1002/EBM2.7
[7]   Leaching of the plasticizer di(2-ethylhexyl)phthalate (DEHP) from plastic containers and the question of human exposure [J].
Erythropel, Hanno C. ;
Maric, Milan ;
Nicell, Jim A. ;
Leask, Richard L. ;
Yargeau, Viviane .
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2014, 98 (24) :9967-9981
[8]   High-fat diet aggravates prenatal low-dose DEHP exposure induced spermatogenesis disorder: Characterization of testicular metabolic patterns in mouse offspring [J].
Fan, Yun ;
Xu, Qiaoqiao ;
Qian, Hong ;
Tao, Chengzhe ;
Wan, Tingya ;
Li, Zhi ;
Yan, Wenkai ;
Niu, Rui ;
Huang, Yuna ;
Chen, Minjian ;
Xu, Qiujin ;
Martin, Elizabeth M. ;
Wang, Xinru ;
Qin, Yufeng ;
Lu, Chuncheng .
CHEMOSPHERE, 2022, 298
[9]   Impact of endocrine-disrupting compounds (EDCs) on female reproductive health [J].
Fowler, Paul A. ;
Bellingham, Michelle ;
Sinclair, Kevin D. ;
Evans, Neil P. ;
Pocar, Paola ;
Fischer, Bernd ;
Schaedlich, Kristina ;
Schmidt, Juliane-Susanne ;
Amezaga, Maria R. ;
Bhattacharya, Siladitya ;
Rhind, Stewart M. ;
O'Shaughnessy, Peter J. .
MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2012, 355 (02) :231-239
[10]   Di-(2-ethylhexyl) phthalate exposure induces female reproductive toxicity and alters the intestinal microbiota community structure and fecal metabolite profile in mice [J].
Fu, Xufeng ;
Han, Hang ;
Li, Yuanyuan ;
Xu, Bo ;
Dai, Wenjie ;
Zhang, Yaoxu ;
Zhou, Feng ;
Ma, Huiming ;
Pei, Xiuying .
ENVIRONMENTAL TOXICOLOGY, 2021, 36 (06) :1226-1242
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