A comprehensive survey into the role of exosomes in pancreatic cancer; from the origin of cancer to the progress and possibility of diagnosis and treatment

被引：7

作者：

Farahmand, Yalda ^{[1
]}

Tehrany, Pooya M. ^{[2
]}

Nazari, Ahmad ^{[3
]}

Nava, Zahra Hamidi ^{[4
]}

Alsaffar, Marwa Fadhil ^{[5
]}

Yazdani, Omid ^{[6
]}

Adili, Ali ^{[7
]}

Esbati, Romina ^{[6
]}

Ghafouri, Kimia ^{[1
]}

机构：

[1] Univ Tehran Med Sci, Sch Med, Tehran, Iran

[2] Natl Univ Malaysia, Fac Med, Bani, Malaysia

[3] Univ Tehran Med Sci, Tehran, Iran

[4] Mazandaran Univ Med Sci, Sari, Iran

[5] Al Mustaqbal Univ Coll, Med Labs Tech Dept, Hillah 51001, Babil, Iraq

[6] Shahid Beheshti Univ, Dept Med, Tehran, Iran

[7] Tabriz Univ Med Sci, Tabriz, Iran

来源：

PATHOLOGY RESEARCH AND PRACTICE | 2023年 / 245卷

关键词：

Pancreatic cancer; Exosomes; Diagnosis; Treatment; TUMOR-DERIVED EXOSOMES; EXTRACELLULAR VESICLES; DRUG-RESISTANCE; CELLS; PROLIFERATION; MICRORNA; BIOMARKERS; MIGRATION; INVASION; RISK;

D O I：

10.1016/j.prp.2023.154465

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Pancreatic cancer is the fourth most common malignant tumor in the world, which has a high mortality rate due to high invasiveness, early metastases, lack of specific symptoms, and high invasiveness. Recent studies have shown that exosomes can be essential sources of biomarkers in pancreatic cancer. Over the past ten years, exosomes have been implicated in multiple trials to prevent the growth and metastasis of many cancers, including pancreatic cancer. Exosomes also play essential roles in immune evasion, invasion, metastasis, proliferation, apoptosis, drug resistance, and cancer stemness. Exosomes help cells communicate by carrying proteins and genetic material, such as non-coding RNAs, including mRNAs and microRNAs. This review examines the biological significance of exosomes in pancreatic cancer and their functions in tumor invasion, metastasis, treatment resistance, proliferation, stemness, and immune evasion. We also emphasize recent advances in our understanding of the main functions of exosomes in diagnosing and treating pancreatic cancer.

引用

页数：9