Succinate Dehydrogenase Defects Giant Renal Cell Carcinoma

被引：2

作者：

Sun, Xia ^{[1
]}

Wang, Guang ^{[1
]}

Huang, Ziye ^{[1
]}

Li, Pei ^{[1
]}

Yang, Bowei ^{[1
]}

Wang, Tianyun ^{[2
]}

Li, Jiongming ^{[1
]}

机构：

[1] Kunming Med Univ, Affiliated Hosp 2, Dept Urol, Kunming, Peoples R China

[2] Kunming Med Univ, Affiliated Hosp 2, Dept Pathol, Kunming, Peoples R China

来源：

UROLOGIA INTERNATIONALIS | 2023年 / 107卷 / 08期

关键词：

Renal cell carcinoma; Succinate dehydrogenase; Renal artery embolization;

D O I：

10.1159/000531059

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Succinate dehydrogenase (SDH)-deficient renal cell carcinoma (RCC) is a new subtype of RCC included in the 2016 edition of the WHO classification in RCC. SDH-defective RCC accounts for 0.05-0.2%, and preoperative diagnosis is difficult. We report a severe adherent RCC of inferior vena cava that underwent open radical nephrectomy after preoperative renal artery embolization. Postoperative histopathological examination diagnosed SDH-defective RCC; the clinicopathological stage was pT2b. After 10 months of follow-up, the patient had no evidence of disease recurrence. For patients with large RCC, interventional embolization can be selected to reduce intraoperative bleeding and blood transfusion, and it is recommended to complete interventional surgery within 3-4 h before surgery. SDH-deficient RCC is difficult to distinguish from other renal tumors in imaging, so immunohistochemical examination of SDHB is recommended for young and middle-aged patients, especially those under 45.

引用

页码：819 / 822

页数：4

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