Association between the copper/selenium ratio and the immune response to SARS-CoV-2 infection

被引：4

作者：

Tashakori, Mahnaz ^{[1
]}

Jamalizadeh, Ahmad ^{[2
]}

Nejad-Ghaderi, Mohsen ^{[2
]}

Hadavi, Maryam ^{[3
]}

Yousefi-Ahmadipour, Aliakbar ^{[1
]}

Moghadam, Fatemeh M. ^{[1
]}

Rahnama, Maryam ^{[4
]}

Haftcheshmeh, Saeed M. ^{[5
]}

Mashayekhi, Kazem ^{[6
,7
]}

Momtazi-Borojeni, Amir A. ^{[8
]}

机构：

[1] Rafsanjan Univ Med Sci, Fac Paramed, Dept Lab Sci, Rafsanjan 7718175911, Iran

[2] Rafsanjan Univ Med Sci, Noncommunicable Dis Res Ctr, Rafsanjan 7718175911, Iran

[3] Rafsanjan Univ Med Sci, Paramed Sch, Dept Anesthesiol, Rafsanjan 7718175911, Iran

[4] Urmia Univ Med Sci, Sch Med, Dept Appl cell Sci, Orumiyeh 571478334, Iran

[5] Neyshabur Univ Med Sci, Hlth Ageing Res Ctr, Neyshabur 9318614139, Iran

[6] Rafsanjan Univ Med Sci, Student Res Comm, Rafsanjan 7718175911, Iran

[7] Rafsanjan Univ Med Sci, Res Inst Basic Med Sci, Immunol Infect Dis Res Ctr, Rafsanjan 7718175911, Iran

[8] Neyshabur Univ Med Sci, Noncommunicable Dis Res Ctr, Neyshabur 9318614139, Iran

来源：

BIOMARKERS IN MEDICINE | 2023年 / 17卷 / 06期

关键词：

copper; COVID-19; Cu; Se ratio; healthcare worker; IgG; selenium; ACUTE-PHASE RESPONSE; COPPER-ZINC RATIO; SELENOPROTEIN EXPRESSION; HEALTH BEHAVIORS; TRACE-ELEMENTS; SELENIUM; COVID-19; SERUM;

D O I：

10.2217/bmm-2022-0530

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aim: To assess the association serum levels of selenium (Se) and copper (Cu) with symptoms and IgG immune response to SARS-CoV-2. Patients & methods/materials: Blood samples and nasopharyngeal swabs were obtained from 126 COVID-19 patients with mild and severe symptoms. The serum levels of Cu and Se were measured by atomic-absorption spectrophotometry. Results & conclusion: Mean Se was higher in patients with mild symptoms and IgG nonresponders, whereas mean Cu was higher in patients with severe symptoms and IgG responders. The Cu/Se ratio was lower in patients with no IgG responses to infection and mild symptoms versus IgG responders with severe symptoms. These results suggest the Cu/Se ratio as a nutritional biomarker of severity and IgG immune response in COVID-19 patients. Plain language summaryThe association between the strong immune response to infections and trace elements such as copper (Cu) and selenium (Se) is well documented. Se and Cu are changed under infectious conditions. Since SARS-CoV-2 causes inflammation in the body, this study was conducted to evaluate the association between serum levels of Se and Cu changes with the symptoms and immune response to SARS-CoV-2, and then assess the Cu/Se ratio. Blood samples and nasopharyngeal swabs were obtained from 126 SARS-CoV-2 participants with mild and severe clinical symptoms. The SARS-CoV-2 infection and immune response to the virus were confirmed in the laboratory. Next, the Se and Cu serum levels were measured. Finally, we analyzed our findings. The median Se levels were higher in patients with mild symptoms (115 mu g/l) in comparison with the severe symptoms group (99 mu g/l), and the mean Se levels were higher in immune nonresponders (110.33 +/- 3.38 mu g/l) in comparison with the immune responders' group (102.42 +/- 1.83 mu g/l). However, the median Cu was higher in participants with severe symptoms (124 mu g/dl) compared with the mild symptoms group (103 mu g/dl), and the mean Cu levels were higher in immune responders (112 +/- 9.98 mu g/dl) in comparison with the immune nonresponders' group (105.1 +/- 9.4 mu g/dl). The Cu/Se ratio was lower (ratio <1) in participants with no responses to infection and mild symptoms versus responders with severe symptoms. Our results suggest that the Cu/Se ratio may act as a nutritional biomarker of severity and immune response in SARS-CoV-2-infected patients.

引用

页码：307 / 317

页数：11

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[1]

Burger T., 2021, INT J BODY MIND CULT, V8, P135

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