Clinicopathological characteristics and survival outcomes in patients with angiosarcoma of breast

被引:9
作者
Li, Junfeng [1 ]
Li, Yunhai [1 ]
Wang, Yuanyuan [1 ]
Li, Zhao [1 ]
Zhang, Huan [1 ]
Gao, Yidan [1 ]
Tan, Jinxiang [1 ,2 ]
机构
[1] Chongqing Med Univ, Dept Breast & Thyroid Surg, Affiliated Hosp 1, Chongqing, Peoples R China
[2] Chongqing Med Univ, Dept Breast & Thyroid Surg, Affiliated Hosp 1, Chongqing 400016, Peoples R China
来源
CANCER MEDICINE | 2023年 / 12卷 / 12期
基金
中国国家自然科学基金;
关键词
angiosarcoma; breast; risk factor; survival; treatment; RADIATION-ASSOCIATED ANGIOSARCOMA; MANAGEMENT; CANCER; GRADE;
D O I
10.1002/cam4.6042
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background Angiosarcoma of the breast is a rare malignancy. There are little data evaluating the survival and estimating the prognostic factors. The best surgical management and the role of systemic adjuvant therapy remain ill-defined. This study aimed to investigate the clinicopathological features, survival, and prognostic factors of breast angiosarcoma.Methods The data on patients diagnosed with breast angiosarcoma were extracted from the Surveillance, Epidemiology, and End Results database (1975-2016). Univariate and multivariate Cox regression analyses were used to estimate the influential prognostic factors. The overall survival (OS) and disease-specific survival (DSS) of patients with breast angiosarcoma were evaluated.Results This study included 656 patients diagnosed with breast angiosarcoma between 1975 and 2016. The 5-year OS rate of all patients was 44.9% (95% CI 40.8-49.0). In both OS and DSS, Kaplan-Meier survival analyses revealed significant differences for both OS and DSS according to age, year at diagnosis, laterality, grade, and stage (all log-rank p < 0.05). Multivariate analysis suggested that lesions of the right breast, poor differentiation, and advanced stage were independent risk factors for OS or DSS (all p < 0.05). Older age was a risk factor in OS, but was protective in DSS. In primary breast angiosarcoma, age, laterality, grade, and stage were independent prognostic factors in OS and DSS (all p < 0.05). Mastectomy was also a risk factor in DSS (p = 0.034). The proportion of patients with grade III and regional disease was larger in the mastectomy group.Conclusion Angiosarcoma of the breast had a poor prognosis. In our study, age, laterality, histologic grade, and stage were identified as significant prognostic factors. Why patients with angiosarcoma of the right breast had a worse prognosis remains equivocal. Mastectomy was adopted more often by surgeons in this cohort study for patients with advanced primary breast angiosarcoma.
引用
收藏
页码:13397 / 13407
页数:11
相关论文
共 34 条
[31]   Prognosis and treatment of non-metastatic primary and secondary breast angiosarcoma: a comparative study [J].
Yin, Ming ;
Wang, Wenge ;
Drabick, Joseph J. ;
Harold, Harvey A. .
BMC CANCER, 2017, 17
[32]   Primary female breast sarcoma: clinicopathological features, treatment and prognosis [J].
Yin, Ming ;
Mackley, Heath B. ;
Drabick, Joseph J. ;
Harvey, Harold A. .
SCIENTIFIC REPORTS, 2016, 6
[33]   Angiosarcoma [J].
Young, Robin J. ;
Brown, Nicola J. ;
Reed, Malcolm W. ;
Hughes, David ;
Wall, Penella J. .
LANCET ONCOLOGY, 2010, 11 (10) :983-991
[34]   Proper treatment of breast angiosarcoma-mastectomy or breast conserving surgery? [J].
Zdravkovic, Darko ;
Granic, Miroslav ;
Crnokrak, Bogdan .
BREAST CANCER RESEARCH AND TREATMENT, 2020, 179 (03) :765-765